MAP2K4 encodes a dual-specificity kinase that belongs to the Ser/Thr protein kinase family. MAP2K4 phosphorylates MAP kinases in response to various environmental stresses or mitogenic stimuli. MAPK8/JNK1, MAPK9/JNK2, and MAPK14/p38 are substrates for MAP2K4

Mar 30, 2025 · MAP2K4 (Mitogen-Activated Protein Kinase Kinase 4) is a Protein Coding gene. Diseases associated with MAP2K4 include Colorectal Cancer and Breast Cancer. Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and Prolactin Signaling.

As selective MAP2K4 inhibitors have recently been developed, this provides a potentially novel combination treatment strategy for KRAS-mutant cancers 17,18. Therefore, MAP2K4 is a new player in the KRAS game that could pave the way for yet unexplored therapeutic strategies in the treatment of KRAS-driven cancers.

MAP2K4 encodes a dual-specificity kinase (mitogen-activated protein kinase kinase 4, or MKK4) that is mutated in a variety of human malignancies, but the biochemical properties of the mutant kinases and their roles in tumorigenesis have not been fully elucidated.

MAP2K4 is targeted by genetic inactivation in ovarian cancer and restricted to high grade serous and endometrioid carcinomas in our cohort. These results indicated that MKK4 acts as a tumor suppressor and may represent an important therapeutic target for the treatment of ovarian cancer

Mitogen-activated protein kinase kinase 4 (MAP2K4) is a gene that encodes a protein that is a member of the MAP kinase family. The protein functions in the signaling of multiple cellular processes including cellular proliferation, differentiation, transcription regulation, …

Nov 25, 2019 · Mitogen-activated protein kinase kinase 4 (MAP2K4) is a member of the mitogen-activated protein kinase (MAPK) activator family. MAPK signaling plays a significant role in cell proliferation, differentiation, transcriptional regulation, and development.

Jun 6, 2013 · In the SAPK pathway, SAPKs are the dominant JNKs activated in response to a variety of cellular stresses, including treatment with interleukin-beta (147720) and tumor necrosis factor-alpha (TNFA, or TNF; 191160). MAP2K4, or SERK1, is a …

Feb 8, 2025 · Title: Long noncoding RNA HNF1A-AS1 regulates proliferation and apoptosis of glioma through activation of the JNK signaling pathway via miR-363-3p/MAP2K4. microRNA-124-3p inhibits tumourigenesis by targeting mitogen-activated protein kinase 4 in …

May 24, 2018 · Our findings suggest that cancers having mutations in MAP3K1 or MAP2K4, which are frequent in tumors of breast, prostate and colon, may respond to MEK inhibitors.