Domain structure and the location of mutations in the human MAFB protein. Each position indicates the amino acid substitution of the observed mutations in patients where mutations …

Dec 25, 2024 · Plays a pivotal role in regulating lineage-specific hematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells. Required for …

MafB is the avian homologue of the murine kreisler gene product (Eichmann et al., 1997) and belongs to the family of Maf proteins, a subgroup of AP-1-type bZip transcription factors. It can …

Jun 2, 2020 · Three independent MAFB heterozygous and homozygous clones with frameshift mutations in the transactivation domain, leading to disruption of the functional full-length …

Jan 15, 2020 · The transcription factor MafB belongs to the Maf family; it specifically binds to the Maf recognition element (MARE) through its DNA binding domain and regulates the …

Nov 22, 2017 · The mafb b337 line has a single C-to-T point mutation in allele 337 that changes a glutamine codon to a stop codon and truncates the protein upstream of the DNA-binding …

May 18, 2022 · MAFB has a pro-ser-thr-rich acidic transcription activation domain at its N terminus, followed by 2 histidine repeats, an extended homology region, a basic DNA-binding …

Mar 5, 2024 · Title: MAFB shapes human monocyte-derived macrophage response to SARS-CoV-2 and controls severe COVID-19 biomarker expression. Reversal of MYB-dependent …

In the bZip domain, MafB shares extensive homology not only with v-Maf but also with other Maf-related proteins. As expected from its structure, MafB forms a homodimer through its leucine …

MafB is a member of the large Maf family of transcription factors that share similar basic region/leucine zipper DNA binding motifs and N-terminal activation domains. Although it is well …