Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such …

Mar 30, 2025 · MMP16 (Matrix Metallopeptidase 16) is a Protein Coding gene. Diseases associated with MMP16 include Seminoma and Glottis Squamous Cell Carcinoma. Among its related pathways are Matrix metalloproteinases and Extracellular matrix organization.

MMP-16 and MMP-24. The two latest additions to the membrane-spanning MMP family are MT3-MMP (MMP-16), first described in 1997 (Matsumoto et al. 1997), and MT5-MMP (MMP-24), first described in 1999 (Llano et al. 1999). These enzymes are still poorly described in literature.

MMP16, a matrix metalloproteinase, also called MT3-MMP, increases expression during the latter parts of intrauterine lung development, and in models of arrested alveolarization, its mRNA expression decreases. Jonathan Pratt, ... Borhane Annabi.

MMP16 is a putative indicator of adverse melanoma prognosis. Expression of MMP-16 in HTB9 and T24 cells increases following transforming growth factorbeta1 treatment. Matrix metalloproteinase 16 (MMP16) was a downstream target of miR-146b-5p.

Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The encoded protein activates MMP2 by cleavage. This gene was once referred to as MT-MMP2, but was renamed as MT-MMP3 or MMP16.

Title: microRNA-4429-5p suppresses the malignant development of colon cancer by targeting matrix metalloproteinase 16. A protective polymorphism in MMP16, improved blood gas levels, and chronic obstructive pulmonary diseases: Family and two population-based studies.

Activates progelatinase A. Involved in the matrix remodeling of blood vessels. Isoform short cleaves fibronectin and also collagen type III, but at lower rate. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells.

Oct 28, 2024 · Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis.

Matrix Metalloproteinase 16 (MMP16) is a type of collagenase enzyme that plays a role in both normal lung development and destructive processes associated with the inflammatory response.