Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such …

Mar 30, 2025 · MMP14 (Matrix Metallopeptidase 14) is a Protein Coding gene. Diseases associated with MMP14 include Winchester Syndrome and Multicentric Osteolysis-Nodulosis-Arthropathy Spectrum. Among its related pathways are Response of endothelial cells to shear stress and Matrix metalloproteinases.

The MMP14 gene (also known as MT1-MMP ) provides instructions for making an enzyme called matrix metallopeptidase 14. Learn about this gene and related health conditions.

MMP-14 is a type I transmembrane matrix-metalloproteinase that decisively determines cancer progression. MMP-14, anchored in the membrane via a C-terminal signal domain, is activated by cleavage of its cysteine-containing propeptide with a furin-like proprotein convertase, as a result of which a zinc ion is activated in its catalytic center.

MMP14, also called MT1-MMP, is a type I transmembrane protein capable of cleaving gelatin, fibronectin, and laminin and is also required for processing and activation of MMP2 (Sato et al., 1994). From: Cell Polarity in Development and Disease, 2018

MMP-14 Is a novel substrate for matriptase, which regulates the levels of MMP-14 on the cell surface. High levels of matriptase in alpha-1 antitrypsin deficiency may contribute to increased extracellular matrix degradation by alveolar macrophages both …

MMP-14 is membrane-bound matrix metalloproteinase (MT1-MMP) with a collagenase activity that permits to remodel tissue and as long as it is membrane bound, enables cells to get through the extracellular matrix. From: Immunotherapy in Resistant Cancer: From the Lab Bench Work to Its Clinical Perspectives, 2021

Using a combination of in silico, in vitro, and ex vivo approaches, we identified matrixmetalloprotease 14 (MMP-14; also known as MT1-MMP), from a panel of candidate proteases that were differentially expressed through the …

Feb 8, 2025 · Title: Increased shedding of PECAM-1 associated with elevated serum MMP-14 levels as new blood indicators of dengue disease manifestation. MMP-14 Exhibits Greater Expression, Content and Activity Compared to MMP-15 in Human Renal Carcinoma.

Sep 17, 2021 · Matrix metalloproteinase 14 (MMP14), also called membrane type 1 metalloproteinase (MT1-MMP), is a member of the MT-MMP subfamily. MMPs are a class of zinc-binding proteinases that contribute to tumor metastasis by …