Stromelysin-3 (SL-3) also known as matrix metalloproteinase-11 (MMP-11) is an enzyme that in humans is encoded by the MMP11 gene. [4] [5] [6] [7]

MMP-11 shows more similarity to the MT-MMPs, is convertase-activatable and is secreted therefore usually associated to convertase-activatable MMPs. Substrates include Col IV, fibronectin, laminin, aggrecan

Nov 13, 2021 · Matrix metalloproteinase 11 (MMP11), a member of the MMP family involved in the degradation of the extracellular matrix, has been implicated in cancer progression.

MMP-11 exerts a dual effect on tumors. MMP-11 promotes cancer development by inhibiting apoptosis and enhancing the invasion of cancer cells. On the other hand, in animal models, MMP-11 plays a negative role against cancer development via the suppression of metastasis . It is important to highlight this dual effect because MMP-11 could function ...

MMP-11, also named stromelysin-3, is a member of the stromelysin subgroup belonging to MMPs superfamily, which has been detected in cancer cells, stromal cells and adjacent microenvironment. Differently, MMP-11 exerts a dual effect on tumors.

MMP-11. The third human stromelysin is MMP-11, which was first described in 1990 in a breast carcinoma cDNA library (Basset et al. 1990). Although MMP-11 is often categorized as a stromelysin, it is very different from the other two proteases in this group.

Matrix metalloproteinase (MMP)-11, or Stromelysin 3, is a particular member of MMP family, a group of zinc-dependent endopeptidases involved in matrix degradation and tissue remodeling. Despite intense efforts since its first characterization 15 years ago, its role and target substrates in …

Sep 1, 2021 · As one of the most widely studied MMPs, MMP-11 is an important protease that is expressed in cancer cells, stromal cells, and the adjacent microenvironment. MMP-11 has a dual effect on tumors. On one hand, MMP-11 promotes tumor development by inhibiting apoptosis and promoting the migration and invasion of cancer cells in the early stage.

Mar 30, 2025 · MMP11 (Matrix Metallopeptidase 11) is a Protein Coding gene. Diseases associated with MMP11 include Cutaneous Fibrous Histiocytoma and Dermatofibrosarcoma Protuberans. Among its related pathways are Matrix metalloproteinases and Integrin Pathway.

Using native HFL1-produced MMP-11 and HT-1080-produced MMP-14 as well as recombinant proteins, we show that MMP-11 is a MMP-14 substrate. MMP-14 cleaves MMP-11 catalytic domain at the PGG(P1)-I(P1')LA and V/IQH(P1)-L(P1')YG scissile bonds, two new cleavage sites.