IL-10 is a cytokine with multiple, pleiotropic, effects in immunoregulation and inflammation. It downregulates the expression of Th1 cytokines, MHC class II antigens, and co-stimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and …

Members of the interleukin (IL)-10 family of cytokines play important roles in regulating immune responses during host defense but also in autoimmune disorders, inflammatory diseases, and cancer.

Apr 14, 2022 · Here, we describe the selective in vitro generation of murine ESAM low CD103-XCR1-CD172a + CD11b + cDC2 from BM by treatment with a combination of Flt3L, LIF, and IL-10 (collectively named as FL10). FL10 promotes common dendritic cell progenitors (CDP) proliferation in the cultures, similar to Flt3L and CDP sorted and cultured in FL10 generate ...

Jun 23, 2023 · Recent evidence proposed IL-10 as a predictor of severity and mortality for patients with acute or post-acute SARS-CoV-2 infection. In this context, IL-10 can act as an endogenous danger signal, released by tissues undergoing damage in an attempt to protect the organism from harmful hyperinflammation.

Interleukin-10 (IL-10) is arguably the most potent anti-inflammatory cytokine. It is produced by almost all the innate and adaptive immune cells. These cells also serve as its targets, indicating that IL-10 secretion and action is highly regulated and perhaps compartmentalized.

Feb 15, 2010 · Interleukin-10 (IL-10) is not a cell type-specific cytokine, but instead it is broadly expressed by many immune cells. Several layers of regulation regulate IL-10 production, including changes...

IL-10 plays a big role in regulating allergies by inhibiting cytokines responsible for allergic inflammation. Interleukin 19 is produced mainly in monocytes, and can be found in big concentrations in patients with allergic disorders and psoriasis.

Jun 10, 2019 · Our results demonstrated potent antitumor effects of CmAb- (IL10) 2 with reduced toxicity. Moreover, we revealed a mechanism of CmAb- (IL10) 2 preventing dendritic cell (DC)-mediated CD8 + tumor-infiltrating lymphocyte apoptosis through regulating IFN-γ production.

The pleiotropic cytokine leukemia inhibitory factor (LIF) is a key gestational factor known to establish dynamic cellular and molecular cross talk at the feto-maternal interface. Previously, we described the regulatory role of the LIF-trophoblast-IL10 axis in the process of macrophage deactivation i …

IL-10 family cytokines exert essential functions to maintain tissue homeostasis during infection and inflammation through restriction of excessive inflammatory responses, upregulation of innate immunity, and promotion of tissue repairing mechanisms.