Tyrosin-protein kinase Lck (or lymphocyte-specific protein tyrosine kinase) is a 56 kDa protein that is found inside lymphocytes and encoded in the human by the LCK gene. [5] The Lck is a member of Src kinase family (SKF) and is important for the activation of T-cell receptor (TCR) signaling in both naive T cells and effector T cells.

Mar 30, 2025 · LCK (LCK Proto-Oncogene, Src Family Tyrosine Kinase) is a Protein Coding gene. Diseases associated with LCK include Immunodeficiency 22 and Severe Combined Immunodeficiency. Among its related pathways are CD28 co-stimulation and Constitutive Signaling by Aberrant PI3K in Cancer.

Associates directly with the cytoplasmic tail of CD2, which leads to hyperphosphorylation and activation of LCK. Also plays a role in the IL2 receptor-linked signaling pathway that controls the T-cell proliferative response. Binding of IL2 to its receptor results in increased activity of LCK.

LCK is a prognostic marker in Bladder urothelial carcinoma, Head and neck squamous cell carcinoma, Skin cuteneous melanoma

In CLL, Lck promotes B-cell receptor (BCR) signaling, contributing to cell survival and glucocorticoid resistance and inhibiting Lck-inducing apoptosis in CLL cell lines. Targeting Lck in CLL is thus valuable for therapy.

In recent years, the lymphocyte-specific protein tyrosine kinase (Lck) has emerged as one of the key molecules regulating T-cell functions. Studies using Lck knock-out mice or Lck-deficient T-cell lines have shown that Lck regulates the initiation ...

Lck, a non-receptor src family kinase, plays a vital role in various cellular processes such as cell cycle control, cell adhesion, motility, proliferation and differentiation. As a 56 KDa protein, Lck phosphorylates tyrosine residues of various proteins such as ZAP-70, ITK and protein kinase C.

Upon TCR engagement, Lck phosphorylates tyrosine residues within the immunoreceptor tyrosine-based activation motifs (ITAMs) of the TCR-associated CD3 chains. Phosphorylated ITAMs act as docking site for the tandem SH2 domains of the tyrosine kinase Zap-70, which is in turn activated by Lck.

Jan 4, 2025 · It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively.

May 1, 2005 · Lck is a 56 kDa phosphoprotein expressed in variety of lymphoid and non-lymphoid cell lineages. Lck contain myristylation sequence, unique amino-terminal regions, followed by Src homology domains SH3 and SH2, a tyrosine kinase catalytic domain, and C …