Growth Factor Receptor-Bound Protein 2 (Grb2) Association with ...
Jul 15, 1998 · In this study, we demonstrated the clear association of HS1 with Grb2, in vitro and in vivo, indicating that HS1 links signaling between Lck and Grb2. The potential physiologic …
GRB2 Nucleates T Cell Receptor-Mediated LAT Clusters That …
GRB2 is a ubiquitously expressed adaptor protein required for signaling downstream of multiple receptors. To address the role of GRB2 in receptor-mediated signaling, the expression of …
Grb2 functions at the top of the T-cell antigen receptor ... - PNAS
Grb2 is a scaffold protein that functions by mediating protein–protein interactions. However, our coimmunoprecipitation assay could not prove any meaningful association between Grb2 and …
Identification of Grb2 As a Novel Binding Partner of the Signaling ...
May 15, 2005 · The phosphorylation of the receptor and Grb2 levels of binding in the transfections with Fyn or Lck were very similar. Thus, both kinases phosphorylate efficiently the Y606 of …
Hypophosphorylated TCR/CD3zeta signals through a Grb2 …
Here we report the recruitment of Grb2-SOS1 to CD3zeta of the TCR complex after prolonged anti-CD3 (OKT3) stimulation in T cells with Lck knockdown. Grb2 bound to incompletely …
Transmission of T Cell Receptor-Mediated Signaling via the GRB2 …
GRB2, GADS, and GRAP are especially vital for the function of T cells. These proteins control signaling complexes at the T cell antigen receptor and the adaptor protein LAT, where they …
Role of Herpes Simplex Virus VP11/12 Tyrosine-Based Motifs in …
We found that inactivating the Grb2 (Y633) and Shc (Y657) binding motifs had little or no effect on Lck activation, while inactivating the p85 motif at Y519 induced a small but statistically …
Reduced Cbl phosphorylation and degradation of the zeta-chain …
Here, we show that short interfering RNA-mediated targeting of Lck caused a dramatic reduction in c-Cbl phosphorylation and a general reduction in protein ubiquitination after TCR …
Grb2 and Gads Exhibit Different Interactions with CD28 and Play ...
Jul 15, 2006 · It has been reported that CD28 associates with signaling proteins such as PI3K, Grb2 family adaptor proteins, Grb2 and Gads/Grf40, Tec family protein tyrosine kinases, Itk …
Systems and computational analysis of gene expression datasets …
Feb 16, 2024 · Our analysis reveals aggressive suppression of GRB-2, an adaptor molecule integral for TCR signaling, as a primary immunomodulatory response against S. typhi infection …