Lecithin–cholesterol acyltransferase (LCAT, also called phosphatidylcholine–sterol O-acyltransferase) is an enzyme found in many animals, including humans. It converts free cholesterol into cholesteryl ester, a more hydrophobic form of cholesterol.

The LCAT gene provides instructions for making an enzyme called lecithin-cholesterol acyltransferase (LCAT). This enzyme plays a role in removing cholesterol from the blood and tissues.

Lecithin cholesterol acyltransferase (LCAT) (EC2.3.1.43), a lipoprotein-associated enzyme, is a key player in the reverse cholesterol transport (RCT) pathway, which promotes the transfer of excess cellular cholesterol from peripheral tissues to the liver for excretion [1].

Lecithin cholesterol acyltransferase (LCAT) is the key enzyme in mediating the esterification of cholesterol on circulating lipoproteins. It has long been suggested that LCAT plays a crucial role in reverse cholesterol transport, a process depicting the removal of cellular cholesterol through efflux to high density lipoproteins (HDL) and its ...

Phosphatidylcholine-sterol O-acyltransferase is another name for LCAT; an enzyme bound to both HDL and LDL in plasma. This enzyme is responsible for the conversion of free cholesterol into cholesterol ester which renders it more hydrophobic ( 3 ).

Mar 1, 2022 · Lecithin: cholesterol acyltransferase (LCAT) is the sole enzyme which can maintain the free cholesterol (FCh) gradient (homeostasis) between peripheral tissues and high-density lipoprotein (HDL) through esterifying FCh and loading it into HDL particles.

LCAT converts free cholesterol to cholesteryl esters in the process of reverse cholesterol transport. Familial LCAT deficiency (FLD) is a genetic disease that was first described by Kaare R. Norum and Egil Gjone in 1967.

Dec 15, 2000 · LCAT is a soluble enzyme that converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lyso-phosphatidylcholines on the surface of high-density lipoproteins.

Jul 5, 2018 · Lecithin:cholesterol acyltransferase (LCAT) (EC2.3.1.43) is the only plasma enzyme capable of catalyzing cholesteryl ester (CE) formation from free cholesterol (FC) and phosphatidylcholine (lecithin).

Dec 15, 2000 · LCAT is a soluble enzyme that converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lyso-phosphatidylcholines on the surface of high-density lipoproteins.