Jun 15, 2011 · Transforming growth factor (TGF)-β is stored in the extracellular matrix as a latent complex with its prodomain. Activation of TGF-β1 requires the binding of α(v) integrin to an RGD sequence in the prodomain and exertion of force on this domain, which is held in the extracellular matrix by latent TG …

Jun 15, 2011 · Here, we describe the structure of latent TGF-β, mechanisms for latency and integrin-dependent activation, and broad implications for the regulation of bioactivity in the TGF-β family.

Dec 22, 2022 · Under enzymatic and non-enzymatic action, latent TGF transforms into activated TGF. Only activated TGF can bind to the TGF receptor complex and induce canonical and noncanonical pathways of TGF-β signal transduction.

May 13, 2021 · Transforming growth factor-β (TGF-β) isoforms are secreted as inactive complexes formed through non-covalent interactions between bioactive TGF-β entities and their N-terminal pro-domains called latency-associated peptides (LAP).

Oct 25, 2018 · Transforming growth factor–β1 (TGF-β1) is one of very few cytokines produced in a latent form, requiring activation to exert any of its vastly diverse effects on development, immunity, and cancer.

LTBPs were discovered as part of a large latent complex with TGFβ and its propeptide (Kanzaki et al. 1990), and were given the name ‘latent TGFβ binding proteins’.

May 15, 2024 · WNT5A was identified as a predominant noncanonical WNT ligand in fibrotic diseases such as systemic sclerosis, sclerodermatous chronic graft-versus-host disease, and idiopathic pulmonary fibrosis, stimulating fibroblast-to-myofibroblast transition and tissue fibrosis by activation of latent TGF-β.

The latent transforming growth factor-β (TGF-β) 1 binding proteins (LTBP-1– 4) are secreted multidomain glycoproteins, three of which are central to TGF-β regulation (1, 2). LTBP-1 is a component of the latent TGF-β complex that consists of …

Transforming growth factor (TGF)-b is stored in the extracellular matrix as a latent complex with its prodomain. Activation of TGF-b1 requires the binding of a v integrin to an RGD sequence in...

The LTBPs (or latent transforming growth factor β binding proteins) are important components of the extracellular matrix (ECM) that interact with fibrillin microfibrils and have a number of different roles in microfibril biology.