Lambda phage is a non-contractile tailed phage, meaning during an infection event it cannot 'force' its DNA through a bacterial cell membrane. It must instead use an existing pathway to invade the host cell, having evolved the tip of its tail to interact with a specific pore to allow entry of its DNA to the hosts.

Phage lambda DNA was one of the earliest model systems for studying the physical nature of DNA and genes, and a substantial amount of early research examined the hydrodynamic properties of the lambda chromosome with the goal of, among other things, determining its absolute molecular weight.

Phage lambda is a virus of E. coli K12 which after entering inside host cell normally does not kill it in-spite of being capable of destroying the host. Therefore, it leads its life cycle in two different ways, one as virulent virus and the second as non-virulent.

Mar 28, 2022 · Lambda phage or coliphage λ is a bacteriophage that infects the bacteria belonging to the members of the bacterial species Escherichia coli . The lambda phage was originally discovered by Esther Lederberg in 1951 in the US during her studies on E. coli under ultraviolet irradiation.

Since the earliest days of molecular biology, bacteriophage lambda has served to illuminate cellular function. Among its many roles, lambda infection is a paradigm for phenotypic heterogeneity among genetically identical cells. Early studies ...

Bacteriophage λ is a temperate phage, which, upon infection of Escherichia coli, enters either the lytic or lysogenic replication pathway. The latter is defined by the integration of the λ prophage within the bacterial host genome, where it is quiescently inherited by daughter cells.

Jan 4, 2024 · Bacteriophage lambda has a double-stranded DNA genome and a long, flexible, non-contractile tail encoded by a contiguous block of 11 genes downstream of the head genes. The tail allows host recognition and delivery of viral DNA from the head shell to the cytoplasm of the infected cell.

Jan 15, 2025 · The lambda phage genome is a linear double-stranded DNA molecule, approximately 48,502 base pairs in length. This genetic material is organized into distinct functional regions, each responsible for specific roles during the phage’s life cycle.

Jan 1, 2016 · It belongs to the family of lambdoid phages, that includes phages ϕ21, ϕ80, ϕ81, etc. Lambdoid phages are characterized by cohesive ends, the ability to recombine, and inducibility by UV.

Jan 9, 2023 · Delve into the captivating world of microbiology as you explore Lambda Phage, a bacteriophage that plays a pivotal role in genetic research. This article breaks down fascinating details of the Lambda Phage structure, its genome size, and its intriguing life cycle.