Lamins, also known as nuclear lamins, are fibrous proteins in type V intermediate filaments, providing structural function and transcriptional regulation in the cell nucleus. Nuclear lamins interact with inner nuclear membrane proteins to form the nuclear lamina on the interior of the nuclear envelope.

Laminins are heterotrimeric proteins with a high molecular mass (~400 to ~900 kDa) and possess three different chains (α, β, and γ) encoded by five, four, and three paralogous genes in humans, respectively. The laminin molecules are named according to their chain composition, e.g. laminin-511 contains α5, β1, and γ1 chains. [3] .

As IF structural proteins, it is now well established that the lamins provide shape and mechanical stability to the nucleus (Houben et al. 2007). There is also evidence supporting a role for the lamins in maintaining the mechanical properties of the entire cell.

Using three-dimensional structured illumination microscopy and computational image analysis, we characterized the supramolecular structures of lamin A, C, B1, and B2 in mouse embryo fibroblast nuclei.

Dec 5, 2012 · Lamin A and lamin C are the major A-type lamins that are expressed in somatic cells, whereas lamin C2 is uniquely expressed in the testis. The minor lamin AΔ10 is also found in somatic...

Feb 8, 2021 · Alterations in nuclear shape are present in human diseases and ageing. A compromised nuclear lamina is molecularly interlinked to altered chromatin functions and genomic instability. Whether...

Feb 1, 2024 · Lamins have three structural regions: a globular amino-terminal head, central α-helical ‘rod’ domain, and a carboxy-terminal tail (Figure 1). The α-helical domain has four coiled coils that mediate dimer formation.

Lamins are nuclear intermediate filament (IF) proteins. They assemble to fibrous structures that are positioned between the inner nuclear membrane and the peripheral chromatin. A small fraction of lamins is also present in the nucleoplasm.

Aug 21, 2019 · Here, we present the crystal structure of a long human lamin fragment at 3.2 Å resolution that allows the visualization of the features of the full-length protein. The structure shows an...

Lamins, the major components of the nuclear lamina, have gained rapidly increasing interest over the past decade as lamin mutations were found to cause numerous devastating diseases.