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Dec 20, 2024 · Monoclonal gammopathy of undetermined significance (MGUS) is a condition in which an atypical protein is found in the blood. The protein is called monoclonal protein or M protein. This protein is made in the soft, blood-producing tissue in the center of bones.

Monoclonal gammopathy of undetermined significance (MGUS) is a clinically asymptomatic premalignant clonal plasma cell or lymphoplasmacytic proliferative disorder.

The most common condition linked with these abnormal proteins is monoclonal gammopathy of undetermined significance (MGUS). MGUS usually causes no symptoms. Diagnosis is often done with a lab test called protein electrophoresis.

Jan 11, 2018 · Monoclonal gammopathy of undetermined significance (MGUS) is, in many ways, a unique hematologic entity. Unlike most hematologic conditions in which the diagnosis is intentional and credited to hematologists, the discovery of MGUS is most often incidental and made by nonhematologists.

These precursor conditions, known as either monoclonal gammopathy of undetermined significance (MGUS) or smoldering multiple myeloma (SMM) are often discovered accidentally during routine bloodwork or urine testing for other conditions.

Dec 10, 2021 · In 1978, Dr Robert Kyle introduced the concept of “monoclonal gammopathy of undetermined significance” (MGUS) given that, at diagnosis, it was not possible with available methods (ie, serum protein electrophoresis to define the concentration of M-proteins and microscopy to determine the plasma cell percentage in bone marrow aspirates) to ...

Initial screening for monoclonal gammopathy includes serum protein electrophoresis (SPEP), serum immunofixation, and free flightchain (FLC). If M-protein is detected, urine protein electrophoresis is ordered.

Monoclonal gammopathy of undetermined significance (MGUS) is a premalignant state for a spectrum of lymphoplasmacytic malignancies. The risk of progression of MGUS to a symptomatic therapy requiring plasma cell dyscrasia is about 1% per year.

Diagnostic criteria for MGUS (Monoclonal Gammopathy of Unknown Significance), asymptomatic myeloma and symptomatic myeloma