KIT is a receptor tyrosine kinase type III, which binds to stem cell factor, also known as "steel factor" or "c-kit ligand". When this receptor binds to stem cell factor (SCF) it forms a dimer that activates its intrinsic tyrosine kinase activity, that in turn phosphorylates and activates signal transduction molecules that propagate the signal ...

The KIT gene provides instructions for making a member of a protein family called receptor tyrosine kinases. Receptor tyrosine kinases transmit signals from the cell surface into the cell through a process called signal transduction.

Mar 30, 2025 · KIT (KIT Proto-Oncogene, Receptor Tyrosine Kinase) is a Protein Coding gene. Diseases associated with KIT include Piebald Trait and Gastrointestinal Stromal Tumor. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and …

Dec 5, 2024 · A KIT mutation increases your risk of gastrointestinal stromal tumors (GISTs). While a KIT mutation means you have a somewhat higher risk of developing cancer than the average person, it may not fully explain why your blood relatives have cancer.

The KIT gene provides instructions for making a member of a protein family called receptor tyrosine kinases. Receptor tyrosine kinases transmit signals from the cell

KIT. The KIT proto-oncogene maps to 4q12 and encodes the 145-kDA transmembrane receptor tyrosine kinase, KIT (CD117), the cellular homolog of the Hardy–Zuckerman 4 feline sarcoma viral oncogene, v-kit [1, 2].

Activated KIT and KIT with the D816V mutation induced HSP32 promoter activity and expression of HSP32 mRNA and protein.

KIT (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, also known as CD117) encodes for the mast/stem cell growth factor receptor Kit protein. It is a receptor tyrosine kinase (RTK) expressed on a wide variety of cell types. The ligand for KIT is stem cell factor (SCF).

Apr 12, 2025 · KIT is the gene encoding a transmembrane tyrosine kinase receptor, involved in both the MAP kinase and AKT pathways, which are intimately involved with cell proliferation and survival (J Clin Oncol 2013;31:3176, Int J Biol Sci 2013;9:435)

This gene encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. This protein is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor).