In enzymology, an IκB kinase (EC 2.7.11.10) is an enzyme that catalyzes the chemical reaction: Thus, the two substrates of this enzyme are ATP and IκB protein, whereas its two products are ADP and IκB phosphoprotein.

We describe here how these studies have identified a unique inhibitor of pro-inflammatory NF- κ B signaling, an unforeseen role for IKK α in the classical NF- κ B pathway, and a novel functional domain in IKK β that is not present in IKK α.

Composed of two serine-threonine kinases (IKKα and IKKβ) and the regulatory subunit NEMO (also known as IKKγ), the IKK complex integrates signals from all NF-κB activating stimuli to catalyze the phosphorylation of various IκB and NF-κB proteins, as well as of other substrates.

Inhibitory kappa B kinase beta (IKKβ), known as IKK2, is a key regulatory kinase responsible for the activation of NF-κB through its phosphorylation at Ser177 and Ser181 to promote the phosphorylation of inhibitors of kappa B (IκBs), triggering their ubiquitination and degradation to active the nuclear factor kappa-B (NF-κB) cascade.

Control over the immune cell functions of NF-κB results from signaling through one of two different routes: the canonical and noncanonical NF-κB signaling pathways. Present at the end of both pathways are the proteins NF-κB, IκB, and the IκB kinase (IKK).

Nov 22, 1999 · Rel/NF-κB transcription factors are primarily regulated by association with inhibitor IκB proteins. Thus, in most cells NF-κB exists in the cytoplasm in an inactive complex bound to IκB. Most...

Oct 17, 1997 · Recently we purified a 900 kDa cytokine-responsive IκB kinase complex (IKK) and molecularly cloned one of its subunits, IKKα, a serine kinase. We now describe the molecular cloning and characterization of IKKβ, a second subunit of the IKK complex.

New work reveals the roles of the three subunits of IKK and how it is regulated. NF-κB represents a family of transcription factors that are normally kept inactive in the cytoplasm through interaction with inhibitory molecules of the IκB family.

Feb 26, 2008 · We proposed that NF-κB transcription factors regulated via the IκB kinase (IKK) complex play a critical role in coupling inflammation and cancer and have set out to test this hypothesis in...

Dec 27, 2013 · Composed of two serine‐threonine kinases (IKK α and IKK β) and the regulatory subunit NEMO (also known as IKK γ), the IKK complex integrates signals from all NF ‐κB activating stimuli to catalyze the phosphorylation of various IκB and NF ‐κB proteins, as well as of other substrates.