May 3, 2018 · Here, we show that cellular stress disrupts nucleocytoplasmic transport by localizing critical nucleocytoplasmic transport factors into stress granules, RNA/protein complexes that play a crucial role in ALS pathogenesis.

Apr 26, 2023 · We identify that toxic dipeptide repeats produced in ALS/FTD conditions activate JNK. The activated JNK in the nucleus can induce histone modifications which increase G3BP1 expression, thus promoting stress granule assembly and neurodegeneration.

‪Junior Principle Investigator, Shenzhen Bay Laboratory‬ - ‪‪Cited by 4,704‬‬ - ‪Neurodegenerative diseases‬

张轲博士在 Nature, Science, Cell, Neuron, Nature Cell Biology 等国际著名期刊上发表研究论文24篇。 其中以第一作者或通讯作者发表文章 10 篇（包括Nature 2篇，Cell 1 篇等）。 总共引用3000多次，h因子18。

Aug 26, 2015 · The hexanucleotide repeat expansion (HRE) GGGGCC (G4C2) in C9orf72 is the most common cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).

c-Jun N-Terminal Kinase Promotes Stress Granule Assembly and Neurodegeneration in C9orf72-Mediated ALS and FTD Sahana, T. G., Chase, K. J., Liu, F., Lloyd, T. E., Rossoll, W. & Zhang, K., Apr 26 2023, In: Journal of Neuroscience. 43, 17, p. 3186-3197 12 p. Research output: Contribution to journal › Article › peer-review

Sep 3, 2015 · Nucleocytoplasmic transport defects may be a fundamental pathway for ALS and FTD that is amenable to pharmacotherapeutic intervention. The hexanucleotide repeat expansion (HRE) GGGGCC (G4C2) in C9orf72 is the most common cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).

2019 Frick Foundation for ALS Research Award. 2018 Springboard Fellowship Award, Target ALS Consortia. 2016 The Helen Taussig Young Investigator Award, Johns Hopkins School of Medicine. 2014 Milton Safenowitz Postdoctoral Fellowship, ALS Association.

Apr 28, 2022 · Here, we show that ER stress activates JNK via IRE1 in fly and cellular. ALS/FTD. Furthermore, activated JNK promotes SG assembly induced by poly(GR) and. a key SG protein. Consistent with these findings, JNK or IRE1 inhibition reduced SG formation, poly(PR) or neurons derived from c9ALS/FTD patient induced pluripotent stem cells (iPSCs). Our.

May 3, 2018 · Our findings identify a link between stress granule assembly and nucleocytoplasmic transport, two fundamental cellular processes implicated in the pathogenesis of C9ORF72 -mediated ALS/FTD and other neurodegenerative diseases.