Potassium voltage-gated channel, shaker-related subfamily, member 3, also known as KCNA3 or Kv1.3, is a protein that in humans is encoded by the KCNA3 gene. [5][6][7] Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints.

Mar 30, 2025 · KCNA3 (Potassium Voltage-Gated Channel Subfamily A Member 3) is a Protein Coding gene. Diseases associated with KCNA3 include Epilepsy and Eye Degenerative Disease. Among its related pathways are Potassium Channels and …

A common genetic variant rs2821557 in KCNA3 is linked to the severity of multiple sclerosis. Kv1.3 voltage-gated potassium channels link cellular respiration to proliferation through a non-conducting mechanism. Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.

We describe a novel association of de novo missense variants in KCNA3 with a human DEE, and provide evidence that fluoxetine might represent a potential targeted treatment for individuals carrying variants with significant GoF effects.

Feb 8, 2025 · Enables voltage-gated potassium channel activity. Predicted to be involved in action potential and potassium ion transmembrane transport. Located in axon and plasma membrane. Is expressed in brain and heart. Orthologous to human KCNA3 (potassium voltage-gated channel subfamily A member 3). [provided by Alliance of Genome Resources, Feb 2025]

KCNA3 is expressed in microglia and likewise in T cells, it is important for their proliferation (Kotecha & Schlichter, 1999). In an attempt to mechanistically define the role of KCNA3 in pro-inflammatory microglia, the effects of blocking the channel were studied in vivo and in vitro (Rangaraju et al., 2017). Using the lipopolysaccharide (LPS ...

Aug 28, 2023 · The potassium voltage-gated channel, shaker-related subfamily, member 3, also known as KCNA3 or Kv1.3, is involved in the repolarization of nerve cells following an action potential. It also plays an essential role in T-cell proliferation and activation.

Mar 1, 2024 · We describe a novel association of de novo missense variants in KCNA3 with a human DEE and provide evidence that fluoxetine might represent a potential targeted treatment for individuals carrying variants with significant GoF effects.

Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog (s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily.

Jan 4, 2025 · Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume.