Anti-Jo-1 autoantibody is the most frequently detected anti-aaRS antibody in ASSD and targets the histidyl tRNA synthetase which catalyses the binding of the histidine to its cognate tRNA during protein synthesis. (4,5).

In these patients a positive result for Jo-1 antibodies may be helpful in selecting appropriate treatment and in prognostication. This study highlights that anti-Jo-1 positivity, in the absence of clear clinical features, has a very low predictive value.

Anti-Jo1 is an anti-nuclear antibody. [1][2] Anti-Jo1 has been associated with inflammatory myopathies such as polymyositis, dermatomyositis and antisynthetase syndrome. [3][4] It has histidine-tRNA ligase as a target. ^ Gutiérrez-Ramos R; Gonzalez-Díaz V; Pacheco-Tovar MG; López-Luna A; Avalos-Díaz E; Herrera-Esparza R (2008).

Anti-Jo-1 autoantibody is the most frequently detected anti-aaRS antibody in ASSD and targets the histidyl tRNA synthetase which catalyses the binding of the histidine to its cognate tRNA during protein synthesis.(4,5).

Anti-Jo-1 antibody is a myositis-specific autoantibody most commonly found in patients with idiopathic inflammatory myopathies (IIM). Presence of Jo-1 (antihistidyl transfer RNA [t-RNA] synthetase) antibody is associated with poly myositis and may also be seen in patients with dermato myositis.

Anti-Jo-1 antibodies are present in approximately 20% to 30% of patients with adult-onset polymyositis syndromes. They are present in >65% of patients with both myositis and interstitial lung disease.

Anti-Jo-1 antibody is a myositis specific autoantibody most commonly found in patients with idiopathic inflammatory myopathies (IIM). This antibody is directed against the histidyl-tRNA synthetase which catalyses the binding of the histidine …

Anti-Jo-1 Ab (RDL), or Anti-Histidyl-tRNA Synthetase Antibody, is a pivotal serological marker extensively used in the diagnosis and management of autoimmune disorders, particularly Idiopathic Inflammatory Myopathies (IIM), including Polymyositis (PM) and Dermatomyositis (DM).

Jo-1 Antibody - Jo-1 Antibody occurs most frequently (31%) in patients with polymyositis, but has also been found in patients with dermatomyositis, and the polymyositis/scleroderma "overlap syndrome" (PM/SCL) or polymyositis/systemic lupus …

Jo-1 is an autoantibody that recognizes a cytoplasmic protein, histidyl-tRNA synthetase, an enzyme important for incorporating histidine into proteins. 58 Jo-1 is a marker of immune-mediated ILD and may be helpful in its early evaluation. 59,60 ANA may be negative in patients positive for Jo-1, although granular histidyl-tRNA synthetase ...