Dec 1, 2021 · JNK can suppress TNF-stimulated apoptosis, but can also potentiate TNF-stimulated necrosis. The increased necrosis is mediated, in part, by a requirement of JNK for TNF-induced production of cytotoxic reactive oxygen species (ROS).

Three groups of MAP kinases can be defined: ERK (extracellular signal-regulated kinase); JNK (c-Jun N-terminal kinase); and p38 MAP kinases. These pathways can be activated by many stimuli, including growth factors, inflammatory cytokines, and a wide spectrum of cellular stresses.

Nov 15, 2018 · Here we showed that c-Jun N-terminal kinases (JNK1 and JNK2) displayed kinase-dependent and -independent functions in regulating TNF- and TLRs-mediated necroptosis. We found that RIPK1 and RIPK3...

The binding of tumour necrosis factor α (TNFα) to cell surface receptors engages multiple signal transduction pathways, including three groups of mitogen-activated protein (MAP) kinases: extracellular-signal-regulated kinases (ERKs); the cJun …

The c-Jun NH2-terminal kinase (JNK) is activated by the cytokine tumor necrosis factor (TNF). This pathway is implicated in the regulation of AP-1-dependent gene expression by TNF. To examine the role of the JNK signaling pathway, we compared the ...

Jan 1, 2005 · JNK is a key regulator of many cellular events, including programmed cell death (apoptosis). In the absence of NF-κB activation, prolonged JNK activation contributes to TNF-α induced apoptosis....

Mar 15, 2006 · In this review we will first summarize and discuss some recent findings regarding the signaling mechanisms of ROS-or RNS-mediated JNK activation. Second, we will talk about the role of JNK in ROS-or RNS-mediated cell death (both apoptosis and necrosis).

These results demonstrate a causal role for JNK and caspases in TNF+CHX-induced apoptosis of Huh7 human hepatoma cells. Therefore, strategies aimed at enhancing both pathways should provide a profitable basis to overcome the resistance …

Feb 20, 2004 · Here, we review recent data on the role of JNK in the regulation of TNF-dependent apoptosis and discuss what is known so far about how cells decide whether to live or die in response to TNF. Tumor necrosis factor-α (TNF) plays a pivotal role in orchestrating innate inflammatory responses in vertebrates.

Jun 17, 2002 · In our large‐scale gain‐of‐function screen, we identified Eiger, the first invertebrate tumor necrosis factor (TNF) superfamily ligand that can induce cell death. Eiger is a type II transmembrane protein with a C‐terminal TNF homology domain. It is predominantly expressed in the nervous system.