Jarid1B (also known as KDM5B or PLU1) is in the family of JHDM genes. These are responsible for demethylation of tri- and di-methylated lysines in the 4 position of histone 3 (H3K4me3 and …

Oct 27, 2020 · CDX2 inhibited by JARID1B-derived H3K4me3 methylation promoted cells proliferation of CRC via Wnt/β-catenin signaling pathway. Therefore, our studies provided a …

JARID1B, a transcriptional repressor, targets genes involved in diverse cellular processes including development, differentiation, and cell cycle (21–23). It is overexpressed in various …

JARID1B or JARID1C deletion can be embryonic lethal, whereas JARID1A knockout mice appear normal [106,107]. In embryogenesis JARID1A and JARID1B have functions in activating the …

Sep 11, 2017 · JARID1 proteins are histone demethylases that both regulate normal cell fates during development and contribute to the epigenetic plasticity that underlies malignant …

JARID1B/KDM5B histone demethylase's mRNA is markedly overexpressed in breast cancer tissues and cell lines and the protein has been shown to have a prominent role in cancer cell …

Nov 11, 2011 · By genome-wide location analysis, we demonstrate that Jarid1b localizes predominantly to transcription start sites of genes encoding developmental regulators, of which …

Jun 16, 2014 · Here, we show that JARID1B, encoding a histone H3 lysine 4 (H3K4) demethylase, is frequently amplified and overexpressed in luminal breast tumors and a …

Jun 1, 2014 · JARID1B, 2 also known as PLU1 or KDM5B, is a histone demethylase that converts tri- and dimethylated lysine 4 in histone H3 (H3K4me3/2) to the monomethylated form …

Oct 27, 2020 · Jumonji AT-rich interactive domain 1B (JARID1B) has been shown to be upregulated in many human cancers and plays a critical role in the development of cancers …