Another important regulator of meiosis and sporulation is the serine/threonine protein kinase Ime2 (12, 24, 34, 48, 49). Diploid cells with deletions of IME2 show a 5- to 12-h delay in the transcription of early meiosis-specific genes, a reduction in their level of expression, and extremely low RNA levels of middle and late genes (34, 49).

Jun 6, 2003 · Ime2 is required for meiotic DNA replication (Foiani et al. 1996) and appears to control the G1–S transition by decreasing the level of Sic1 (Dirick et al. 1998), an inhibitor of the cyclin-dependent kinase (CDK) Cdc28 in the mitotic cell cycle (Mendenhall and Hodge 1998).

Dec 11, 2006 · The IME2 gene is one of the key regulators of the initiation of meiosis in budding yeast. This gene is repressed during mitosis through the repressive chromatin structure at the promoter, which is maintained by the Rpd3-Sin3 histone deacetylase (HDAC) complex.

Inducer of meiosis 2 (Ime2), a protein kinase that has been identified in diverse fungal species, functions in the regulation of various cellular processes, such as ascospore formation, pseudohyphal growth, and sexual reproduction. In this study, ...

Jun 8, 2010 · We demonstrate that meiosis in budding yeast is insensitive to drastic changes in the levels of its consecutive positive regulators (Ime1, Ime2, and Ndt80). Entry into DNA replication is not correlated with the time of transcription of the …

Feb 9, 2011 · Ime2 of the budding yeast Saccharomyces cerevisiae belongs to a family of conserved protein kinases displaying sequence similarities to both cyclin-dependent kinases and mitogen-activated protein kinases. Ime2 has a pivotal role for meiosis and sporulation.

Nov 1, 1995 · Ime2p is a protein kinase that is expressed only during meiosis in Saccharomyces cerevisiae. Ime2p stimulates early, middle, and late meiotic gene expression and down-regulates expression of...

View all IME2 alleles in SGD search. GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies (Molecular Function, Biological Process, and Cellular Component), a …

Feb 13, 2004 · We propose that Ime2 directly catalyzes RPA phosphorylation in the primary reaction and indirectly promotes the Mec1-dependent secondary reaction by advancing cells through meiotic progression. Our studies have identified a novel meiosis-specific reaction that targets a key protein required for DNA replication, repair, and recombination.

Sep 18, 1998 · Destruction of Sic1 and activation of a Clb5-dependent kinase in meiotic cells required the action of the meiosis-specific protein kinase Ime2, thereby coupling early meiotic gene expression to control of DNA replication for meiosis.