Apr 4, 2023 · DoD IL4 overview. The Defense Information Systems Agency (DISA) is an agency of the US Department of Defense (DoD) that is responsible for developing and maintaining the …

The interleukin 4 (IL4, IL-4) is a cytokine that induces differentiation of naive helper T cells (T h 0 cells) to T h 2 cells. Upon activation by IL-4, T h 2 cells subsequently produce additional IL-4 in …

IL-4 plays important roles in a myriad of cellular events, making it difficult to study its effects, particularly in vivo, on any one system. Although this review focuses on its neurological …

STAT6 is so vital for the actions of IL-4 that Stat6-deficient mice phenocopy many of the defects observed with Il4- or Il4ra-deficient mice (e.g., related to Th2 differentiation and Ig class switch).

Mar 30, 2025 · IL4 is considered an important cytokine for tissue repair, counterbalancing the effects of proinflammatory type 1 cytokines, however, it also promotes allergic airway …

Sep 7, 2021 · Interleukin-4 (IL-4) is a four-α-helical bundle type I cytokine with broad pleiotropic actions on multiple lineages. Major actions of IL-4 were initially discovered for B and T cells, …

SNPs in IL4, IL13 and the receptor subunits are reportedly associated with glioma (111, 112). These polymorphisms highlight key features of IL-4/-13 receptor signaling that regulate …

Jul 1, 2003 · Acute expression of the IL4 gene by differentiated T H 2 cells is regulated by many positive and negative inducible transcription factors, such as nuclear factor of activated T cells …

Interleukin-4 (IL4) is a growth factor for both B and T lymphocytes. - High levels of IL4Rs have been observed on tumors derived from such cells. - IL4Rs are also overexpressed on …

Interleukin-4 is a multifunctional cytokine that plays a critical role in the regulation of immune responses. Its effects depend upon binding to and signaling through a receptor complex …