Interleukin 21 receptor is a type I cytokine receptor. IL21R is its human gene. [5] The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21).

IL-21 produced by follicular helper CD4 T cells (T FH) acts directly on B cells via their IL-21 receptors (IL21R) to generate high-affinity, class-switched antibodies [1, 2].

Mar 30, 2025 · IL21R (Interleukin 21 Receptor) is a Protein Coding gene. Diseases associated with IL21R include Immunodeficiency 56 and Cryptosporidiosis-Chronic Cholangitis-Liver Disease Syndrome. Among its related pathways are Cytokine Signaling in …

Patients with primary immunodeficiency caused by IL21R or IL21 mutations have been described 6 – 9, and their phenotypes have provided invaluable insights into the role of IL-21 in host defense.

Its private receptor, IL-21R, has been shown to activate the Janus kinase/signal transducers and activators of transcription signaling pathway upon ligand binding. Initial studies have demonstrated that IL-21 has pleiotropic effects on the proliferation, differentiation, and effector functions of B, T, natural killer, and dendritic cells.

Apr 22, 2014 · Interleukin-21 (IL-21) binding stabilizes the complex between the IL-21 receptor (IL-21R) and the common cytokine-γ chain, γ c, leading to the activation of Janus kinase 1...

Feb 8, 2025 · Interleukin-21 receptor signaling promotes metabolic dysfunction-associated steatohepatitis-driven hepatocellular carcinoma by inducing immunosuppressive IgA [+] B cells. ChIP-seq analysis found IL21R, a target gene of GTF2I-the susceptibility gene for primary biliary cholangitis in Chinese Han.

Dec 9, 2024 · Gene target information for IL21R - interleukin 21 receptor (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.

Mar 5, 2024 · Clinical resource with information about IL21R, A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci., Cryptosporidiosis-chronic cholangitis-liver disease syndrome, IL21R and PTH may underlie variation of femoral neck bone mineral density as revealed by a genome-wide ...

Patients tend to have normal numbers of lymphocytes, but show defective class-switched B-cells, low IgG, defective antibody response, and defective T-cell responses to certain antigens. …