Mar 30, 2025 · IL12RB2 (Interleukin 12 Receptor Subunit Beta 2) is a Protein Coding gene. Diseases associated with IL12RB2 include Dyskeratosis Congenita, Autosomal Dominant 6 and Leprosy. Among its related pathways are Akt Signaling and Interleukin-12 family signaling.

IL12RB2 is its human gene. [5] IL12RB2 orthologs [6] have been identified in all mammals for which complete genome data are available. The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex.

IL12RB2 is a prognostic marker in Head and neck squamous cell carcinoma, Kidney renal papillary cell carcinoma, Ovary serous cystadenocarcinoma, Rectum adenocarcinoma

data clearly support the IL12RB2 genetic association with systemic sclerosis (SSc), and suggest a relevant role of the interleukin 12 signaling pathway in SSc pathogenesis. Our results support a potential influence of the rs3790567 IL12RB2 polymorphism …

Consistently, neoplastic immune evasion strategies from IL-12-induced anti-tumor immunity exist, since B cells in various chronic lymphoproliferative disorders may silence the gene for IL-12Rβ2 (Il12rb2) by methylation (Airoldi et al., 2004), which was associated with enhanced tumor-cell survival and proliferation in vivo (Airoldi et al., 2005).

Dec 22, 2020 · When expressed in COS-7 cells, IL12RB2 exists as a disulfide-linked oligomer with an apparent monomeric molecular mass of 130 kD. Functional studies indicated that high affinity IL12R is composed of at least 2 beta-type cytokine receptor subunits, each independently exhibiting low affinity for IL12.

Sep 18, 2024 · Title: An ankylosing spondylitis-associated genetic variant in the IL23R-IL12RB2 intergenic region modulates enhancer activity and is associated with increased Th1-cell differentiation.

Taken together, these data show that there is differential regulation of IL-12Rbeta2 expression by IFN-alpha and IFN-gamma on human T and NK cells. The biological activities of IL-12 are mediated through a specific, high-affinity receptor composed of IL-12 receptor (R)beta1 and IL-12Rbeta2 subunits that exist primarily on T and NK cells.

Dec 31, 2013 · Development of a model to study the effect of amino acid changes in IL-12Rβ2. The model can distinguish between deleterious, intermediate and innocuous effects. The IL-12Rβ2 variants N271Y, R313G, A604V and L808R affect receptor function.

Sep 25, 2023 · To identify the mechanism by which IL-12 limits immunopathology in CNS neuroinflammation, we first generated a conditional strain of IL-12-specific receptor subunit b2: Il12rb2fl (ref. 9). We...