Oct 10, 2017 · Here we discovered a positive correlation between IL-10 and IL-10 receptor (IL-10R) expression in the lung with tumour diameter in patients with lung cancer (non-small cell lung cancer), the...

Browse primary antibodies for WB, Flow, IHC, ICC/IF,... Antibodies that detect IL-10 can be used in several scientific applications, including ELISA, Western Blot, Flow Cytometry, Immunohistochemistry and Neutralization. These antibodies target IL-10 in Human, Mouse, Rat, Bovine and Equine samples.

IL-10 is a cytokine with multiple, pleiotropic, effects in immunoregulation and inflammation. It downregulates the expression of Th1 cytokines, MHC class II antigens, and co-stimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and …

We found that Il10 −/− /hIL10BAC mice (which only express human IL-10) competently regulate IL-10-target genes and normalize sensitivity to LPS-induced lethality observed in Il10 −/− mice, presumably by human IL-10 derived from myeloid sources. Indeed, human IL-10 is faithfully expressed in hIL10BAC bone marrow-derived macrophages (BMM ...

Jun 23, 2023 · Interleukin-10 (IL-10) is a pleiotropic cytokine that has a fundamental role in modulating inflammation and in maintaining cell homeostasis. It primarily acts as an anti-inflammatory cytokine, protecting the body from an uncontrolled immune response, mostly through the Jak1/Tyk2 and STAT3 signaling pathway.

IL-10 family cytokines exert essential functions to maintain tissue homeostasis during infection and inflammation through restriction of excessive inflammatory responses, upregulation of innate immunity, and promotion of tissue repairing mechanisms.

We sought to evaluate the effect of interleukin 10 (IL-10) blockade on endogenous T cell and chimeric antigen receptor T (CAR-T) cell antitumour function in CRLM slice cultures.

Rabbit Polyclonal IL-10 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human IL10 aa 100 to C-terminus conjugated to Keyhole Limpet Haemocyanin.

Dec 13, 2011 · IL-10 induces CD8+ T cell infiltration and their cytotoxic activity within pre-established tumors. By induction of IFNγ in CD8+ T cells, IL-10 induces expression of intratumoral antigen presenting molecules.

Interleukin 10 (IL-10) is a 178 amino acid protein that is primarily secreted by TH2 clones. IL-10 has dual functions, the first of which is the suppression of cytokine production by TH1 clones responding to antigen presented by monocyte and macrophage antigen presenting cells (APCs).