The Regulatory Role of IL-10 in Neurodegenerative Diseases
In the course of CNS pathology, the levels of IL-10 significantly increase in the brain in order to ensure nervous tissue survival and mitigate inflammatory responses triggering several …
Novel Influences of IL-10 on CNS Inflammation Revealed by …
Coordinated interactions between cytokine signaling and morphological dynamics of microglial cells regulate neuroinflammation in CNS injury and disease. We found that pro-inflammatory …
The Interleukin-10 Family of Cytokines and Their Role in the CNS
In the present review article, we discuss the evidence for the production of IL-10 by glia, and describe the ability of CNS cells, including microglia and astrocytes, to respond to this …
The Interleukin-10 Family of Cytokines and Their Role in the CNS
Nov 27, 2018 · In the present review article, we discuss the evidence for the production of IL-10 by glia, and describe the ability of CNS cells, including microglia and astrocytes, to respond to …
Balancing the immune response in the brain: IL-10 and its …
Nov 24, 2016 · Interleukin (IL)-10, an anti-inflammatory cytokine, prevents immunopathology in several diseases and disease models, both in the periphery and in the CNS. Here, we review …
The CSF IL-10 concentration is an effective diagnostic marker in ...
Our study confirmed that IL-10 is a useful biomarker for the diagnosis of PCNSL. We highlight new findings showing that the IL-10 level in the CSF could be used as a surrogate marker for …
The T cell response to interleukin 10 alters cellular dynamics and ...
Jul 7, 2012 · IL10 can regulate genes inhibiting cell cycle progression. In accordance with this, we observe that WT T cells proliferate less rapidly than IL10Rα Tdel cells in the CNS in vivo. …
Interleukin-10 in the brain - PubMed
Interleukin (IL)-10 is synthesized in the central nervous system (CNS) and acts to limit clinical symptoms of stroke, multiple sclerosis, Alzheimer's disease, meningitis, and the behavioral …
Yogev et al. report that IL-10 is not only anti-inflammatory but also has an important pro-inflammatory function. T-cell-derived IL-10 regulates the survival of pro-inflammatory T cells …
IL-10 within the CNS is necessary for CD4+ T cells to mediate ...
In the present study, the role of IL-10 in mediating neuroprotection following a facial nerve axotomy model in Rag2- and IL-10-deficient mice was investigated. Results indicate that IL-10 …