Dec 7, 2023 · Learn how Microsoft meets Department of Defense (DoD) Impact Level 5 (IL5) standards.

Interleukin 5 (IL-5) is an interleukin produced by type-2 T helper cells and mast cells.

IL-5 is an interdigitating homodimeric glycoprotein and a member of the four α helical bundle motifs that are conserved among hematopoietic cytokines. IL-5 exerts its effects on target cells via IL-5R, comprising an IL-5α and βc subunit.

Interleukin 5 (IL-5) plays a critical role in maturation, differentiation, activation and tissue recruitment of eosinophils [36]. Mepolizumab and reslizumab — both humanized anti-IL-5 antibodies — are highly specific anti-eosinophil drugs.

Interleukin-5 (IL-5) exerts a central pathogenic role in differentiation, recruitment, survival, and degranulation of eosinophils. Indeed, during the last years, significant advances have been made in our understanding of the cellular and molecular ...

Apr 19, 2024 · DoD Impact Level 5 is designed for unclassified National Security Systems (NSSs) supporting DoD missions. It is intended for systems and data covering Controlled Unclassified Information (CUI) that require a higher level of protection than IL4 .

While interleukin-5 (IL-5) is initially identified by its ability to support the growth and terminal differentiation of mouse B cells in vitro into antibody-secreting cells, recombinant IL-5 exerts pleiotropic activities on various target cells including B cells, eosinophils, and basophils.

Oct 9, 2009 · IL-5 was originally defined as a T-cell-derived cytokine that triggers activated B cells for terminal differentiation into antibody-secreting plasma cells, at least in mice. Concurrently, IL-5 was recognized as the major maturation and differentiation factor …

IL-5 is the predominant cytokine associated with antigen-induced eosinophilic inflammation in the lung. The activation of Th-2 cells leads to the production of IL-5. The pro-eosinophilic effects of IL-5 include: (1) enhanced replication and differentiation of eosinophilic myelocytes; (2) enhanced de …

IL-5 is a potential biomarker which predicts germinal center activity, follicular helper T-cells activity, and neutralization breadth in the HIV-Infected pediatric population. CST1 enhanced eosinophil activation and recruitment through induction of IL-5.