Advances of Wnt Signalling Pathway in Colorectal Cancer
Recently, the author established the relationship between cytosolic IRF3 and Wnt/β-catenin signalling via AOM/DSS-induced chronic colonic inflammation mice models, demonstrating …
IRF3 prevents colorectal tumorigenesis via inhibiting the …
Nov 13, 2020 · Here, we unexpectedly found that the IRF3 deficient mice are hyper-susceptible to the development of intestinal tumor in AOM/DSS and Apc min/+ models. Genetic ablation of …
Targeting 7-Dehydrocholesterol Reductase Integrates Cholesterol ...
Interferon regulatory factor 3 (IRF3) serves as the key signal mediator and transcription factor for the induction of IFN-I. Upon pathogen infection, IRF3 undergoes serial processes of …
Here, we found an intriguing function of cytosolic IRF3 in resting state to inhibit colorectal tumorigenesis via the prevention of Wnt/-catenin signaling. IRF3 binds to the armadillo repeats...
β‐catenin regulates IRF3‐mediated innate immune signalling in ...
Mechanistically, we found that β‐catenin interacted with IRF3 and blocked its nuclear translocation. Our study reveals an unprecedented role of β‐catenin in enabling innate immune …
Genome-wide RNAi Screen Reveals a New Role of a WNT…
Jun 13, 2013 · On the basis of these observations, we propose a novel role of a canonical-like WNT/CTNNB1 signaling pathway in a feedback inhibition of the antiviral innate immune …
A MicroRNA Screen Identifies the Wnt Signaling Pathway as a …
Apr 4, 2017 · We found that this network intersects the IRF3 terminal signaling pathway and that its repression results in the induction of the IRF3-mediated antiviral response when cells are …
Condensation of cellular prion protein promotes renal ... - Science
6 days ago · Administration of siRNA against Irf3 blocked PrP C-elevated Fn1 and Acta2 mRNA and fibronectin and α-SMA protein, respectively, in NRK-52E cells (Fig. 6, C ... Wnt signaling …
The impact of an RNA-binding protein group on regulating the …
1 day ago · Our findings offer novel insights into the regulatory network of Wnt pathway-related RBPs and their potential clinical value in HCC. ... development. Specifically, ILF3 primarily …
GEO Accession viewer - National Center for Biotechnology Information
Nov 24, 2020 · Therefore, our study identifies IRF3 as a negative regulator of the Wnt/β-catenin pathway and a potential prognosis marker for Wnt-related tumorigenesis, and describes an …
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