IRF3 - Wikipedia
IRF3 is a member of the interferon regulatory transcription factor (IRF) family. [5] IRF3 was originally discovered as a homolog of IRF1 and IRF2 . IRF3 has been further characterized …
X-ray crystal structure of IRF-3 and its functional implications
Dec 1, 2003 · Here we present the X-ray crystal structure of the C-terminal regulatory domain of IRF-3 (175-427) (IRF-3 175C) at a resolution of 2.3 A. IRF-3 175C is structurally similar to the …
Bipartite Nuclear Localization Signal Controls Nuclear Import and …
Jul 1, 2015 · IFN regulatory factor (IRF)3 is a master transcription factor responsible for the induction of type I IFN, which plays a crucial role in host antiviral innate immune responses. …
The multiple roles of interferon regulatory factor family in health …
Oct 9, 2024 · In mammals, nine IRF members have been reported, 10 designated as IRF1 (also known as MAR), IRF2, IRF3, IRF4 (known alternatively as LSIRF/ICSAT/ PIP), IRF5, IRF6, …
Structures of apo IRF-3 and IRF-7 DNA binding domains: effect of loop ...
May 19, 2011 · To characterize the conformational changes that occur on DNA binding and how they differ between IRF family members, we have solved the X-ray structures of IRF-3 and IRF …
Structure of IRF-3 Bound to the PRDIII-I Regulatory Element of the ...
Jun 8, 2007 · We show that four IRF-3 molecules bind in tandem to, variably spaced, consensus and nonconsensus IRF sites on the composite element. The ability of IRF-3 to bind these …
IRFs: master regulators of signalling by Toll-like receptors and ...
Sep 1, 2006 · IRF7 is essential for the robust type I IFN gene induction that is elicited by ligation of TLR7 or TLR9, whereas IRF5 is required for the induction of pro-inflammatory cytokine …
The African Swine Fever Virus Virulence Determinant DP96R …
The IRF3 protein possesses a bipartite NLS that is defined by two clusters of basic amino acids: one formed by lysine 77 (K77) and arginine 78 (R78), located at the minor binding site, and the …
Domain mapping of binding region within IRF3. (A) Schematic ...
IRF3 contains a DNA-binding domain (DBD, aa 1 to 113) with an embedded bipartite nuclear localization signal (s) (NLS; K77/R78 and R86/K87), a nuclear export signal (NES; aa 139 to …
The Structural Basis of IRF-3 Activation Upon Phosphorylation
Size-exclusion chromatography and cell-based studies show that mutations of key residues interacting with pSer386 severely impair IRF-3 activation and IFN-β induction. By contrast, …