IQGAP1 is now recognized as a protein scaffold that integrates signals regulating cell adhesion, actin cytoskeleton, the cell cycle, [9] and other cellular functions. IQGAP is particularly interesting as a therapeutic target since it acts as a node for so many signaling pathways implicated in cancer progression.

Mar 30, 2025 · IQGAP1 (IQ Motif Containing GTPase Activating Protein 1) is a Protein Coding gene. Diseases associated with IQGAP1 include Gastric Cancer and Nephrotic Syndrome, Type 3. Among its related pathways are Signaling downstream of RAS mutants and Signaling by …

We and others have identified IQ-motif-containing GTPase-activating protein 1 (IQGAP1), a scaffolding protein involved in the regulation of actin and microtubule organization, cell migration and cell proliferation, as a key regulator of multiple small GTPases and small GTPase functions (Fig. 1). 15,23- 25 Supporting a role for IQGAP1 regulating ...

Apr 23, 2023 · IQGAP1 is the best characterized, with >150 interactors identified (Hedman et al., 2015). IQGAP1 scaffolds many signaling molecules in different signaling pathways (Table 1), including the mitogen-activated protein kinase (MAPK; Box 2) and the class I phosphatidylinositol 3-kinase (PI3K)/Akt (Box 3) networks.

Over 100 unique IQGAP1 interacting proteins have been identified, implicating IQGAP1 as a critical integrator of cellular signaling pathways. Initial research established functions for IQGAP1 in cell-cell adhesion, cell migration, and cell signaling.

interaction of calmodulin with IQ motifs Rac1 enhances the accumulation of actin filaments, E-cadherin, and beta-catenin by acting on IQGAP1. IQGAP1 has a fundamental role in cell motility and invasion differential requirement for efficient GTP hydrolysis by the Sar1p GTPase in export of cargo from the endoplasmic reticulum

Nov 21, 2016 · The scaffold protein IQGAP1 is now shown to orchestrate the assembly of a multi-enzyme complex that streamlines PtdIns (3,4,5)P 3 synthesis to facilitate Akt activation in response to...

IQGAP1 was identified in 1994 as a widely expressed IQ domain-containing protein with a region containing sequence similarity to the Ras GTPase-activating proteins. IQGAP1 has roles in many different aspects of cell physiology and interacts with numerous proteins.

Mar 1, 2012 · IQGAP1 is a 190-kDa protein and its functional domains indicate that it is a critical regulator of development and functions in multiple cell types. It was identified in 1994 as a widely expressed IQ domain-containing protein (9).

Jun 24, 2004 · IQGAP1 is a scaffolding protein that controls cellular motility and morphogenesis by interacting directly with cytoskeletal, cell adhesion, and small G proteins, including Rac1. In this study, we show that IQGAP1 is robustly expressed in ECs and binds to the VEGFR2.