The cellular source of the IL-5 was group 2 innate lymphoid cells (ILC2) infiltrating the infected lungs. Interestingly, the progressive accumulation of eosinophils following virus clearance is reflected in the rapid expansion of c-kit⁺ IL-5 producing ILC2.

Dec 4, 2024 · We demonstrate that B1 cells fail to develop properly in the absence of ILC2s and identify the IL-33 receptor on ILC2s as an essential cell-intrinsic regulator of IL-5 production. Further,...

Dec 4, 2014 · In mice, low-dose IL-2–anti-IL-2 antibody complexes drove group 2 innate lymphoid cells (ILC2) to produce IL-5 and proliferate. Using genetic approaches in mice, we demonstrate that activation of ILC2 was responsible for the eosinophilia observed with IL-2 therapy.

Sep 11, 2023 · In particular, the SCFA butyrate negatively regulates ILC2 functions through HDAC inhibition, which suppresses the expression of GATA3 and its downstream genes, including Il13 and Il5.

Sep 15, 2013 · ILC2 cells secrete IL-5 constitutively and are induced to co-express IL-13 during type 2 inflammation, resulting in localized eotaxin production and eosinophil accumulation.

Group 2 innate lymphoid cells (ILC2) have emerged as a major component of type 2 inflammation in mice and humans. ILC2 secrete large amounts of interleukins 5 and 13, which are largely responsible for host protective immunity against helminth ...

Upon activation by cytokines released from epithelial and stromal cells during tissue damage or stimulation, ILC2s produce copious amounts of IL-5 and IL-13, leading to type 2 inflammation. Over the past 10 years, ILC2 involvement in a variety of human diseases has been unveiled.

Sep 19, 2013 · We show that a newly discovered cell type, the group 2 innate lymphoid cell (ILC2), is responsible for IL-5 production during influenza infection and that the capacity of ILC2 to make IL-5 is greatly increased following virus clearance, i.e. during the recovery phase.

Naive lung ILC2 are primed to secrete IL-5, as indicated by elevated Il5 transcript ( 65) and constitutive Il5-reporter expression ( 14). ILC2-derived IL-5 is important for eosinophilic homeostasis, whereas the local production of IL-13 and the eosinophil-recruiting chemokine eotaxin is essential for eosinophilic lung inflammation following ...

Jan 14, 2022 · Our results demonstrate that BATF broadly and directly controls core functional gene expression of pulmonary ILC2s during influenza virus infection, such as Il5, Il6, Il9, Il13, and Areg. Numerous studies have shown that all these cytokines play beneficial roles in …