The Interleukin-1 family (IL-1 family) is a group of 11 cytokines that plays a central role in the regulation of immune and inflammatory responses to infections or sterile insults.

The interleukin-1 (IL-1) family of cytokines and receptors is unique in immunology because the IL-1 family and Toll-like receptor (TLR) families share similar functions. More than any other …

Jun 6, 2019 · IL-1 blockade therapy using anakinra is successful in patients with psoriatic arthritis, ankylosing spondylitis, and RA.

Jan 18, 2010 · This Review provides a comprehensive and contemporary overview of the interleukin-1 (IL-1) family: their expression and regulation, their effects on innate immune cells, …

IL-1–type cytokines are major mediators of innate immune reactions, and blockade of the founding members IL-1α or IL-1β by the interleukin-1 receptor antagonist (IL-1RA) has …

Apr 7, 2011 · The IL-1 family of receptors is unique in its class of Ig-like receptors because of the presence of the TIR domain in cytoplasmic segment of each member (reviewed in O'Neill 13 ). …

IL-1 activates cells of the innate and adaptive immune system and exerts a wide range of biological activities that are protective during infection, such as promoting fever, vasodilation, …

Jan 19, 2010 · This pathway summarizes extracellular and intracellular signaling of IL-1alpha or IL-1beta, including positive- and negative-feedback mechanisms that amplify or terminate the …

IL-1 was originally identified as endogenous pyrogen and has long been known to regulate sleep, appetite, and the hypothalamus-pituitary-adrenal axis. IL-1 has functions in the brain unrelated …

The interleukin (IL)-1 family of cytokines is currently comprised of 11 members that have pleiotropic functions in inflammation and cancer. IL-1α and IL-1β were the first members of the …