As IGF-1 is related to a high glycemic index, it is plausible that a strict diet may be helpful for controlling acne, possibly through the inhibition of sebum production and inflammation in sebocytes.

IGF-1 increases expression of sterol response element binding protein-1 (SREBP-1), a transcription factor that regulates numerous genes involved in lipid biosynthesis. SREBP-1 expression in turn stimulates lipogenesis in sebocytes.

In this study, we demonstrated that bilobetin inhibited IGF-1–induced sebum production in sebocytes. Bilobetin significantly inhibited IGF-1–induced increase of lipogenic regulators including SREBP-1 and SREBP-2. Furthermore, bilobetin significantly blocked IGF-1–induced activation of AKT signaling.

IGF-1 increases expression of sterol response element-binding protein-1 (SREBP-1), a transcription factor that regulates numerous genes involved in lipid biosynthesis. SREBP-1 expression, in turn, stimulates lipogenesis in sebocytes.

Maximum sebum production begins during puberty, which coincides with the peaking levels of growth hormone and insulin-like growth factor 1 (IGF-1) that occur in midpuberty. 1, 2 Accordingly, elevated levels of growth hormone and IGF-1 may play a role in the development of acne.

Deeper insights into IGF-1-mediated signal pathway are critical importance to understand the impact of Western diet. Objective: We investigated the effect of IGF-1 on the expression of inflammatory biomarkers and sebum production in cultured sebocytes.

IGF-1 stimulates 5alpha-reductase, adrenal and gonadal androgen synthesis, androgen receptor signal transduction, sebocyte proliferation and lipogenesis. Milk consumption results in a significant increase in insulin and IGF-1 serum levels comparable with high glycaemic food.

Jun 1, 2006 · Here we report that: (1) the increased lipogenesis observed in SEB-1 cells treated with methylisobutylxanthine, dexamethasone, and a high dose of insulin (MDI) is attributed to insulin; (2) physiologically relevant doses of IGF-1 increase lipogenesis in SEB-1 sebocytes; and (3) increased expression of SREBP-1 mRNA and protein mediates the ...

May 1, 2019 · In this study, we demonstrated that bilobetin inhibited IGF-1–induced sebum production in sebocytes. Bilobetin significantly inhibited IGF-1–induced increase of lipogenic regulators including SREBP-1 and SREBP-2. Furthermore, bilobetin significantly blocked IGF-1–induced activation of AKT signaling.

Feb 1, 2017 · IGF-1 at concentrations of 0.1 and 1 μM significantly reduced proliferation but increased differentiation of sebocytes to a greater extent than insulin (0.1 and 1 μM), but up-regulated TLR2/4...