IGF-1 system has several pleiotropic effects on biological aging (Figure 1). IGF-1 plays a relevant role in fetal development, growth during childhood and adolescence, and adult tissue homeostasis.

Jun 19, 2018 · Given the conserved role of this pathway on lifespan, therapeutic strategies, such as insulin-like growth factor-1 receptor (IGF-1R) monoclonal antibodies (mAb), represent a promising...

Secretion of growth hormone (GH), and consequently that of insulin-like growth factor 1 (IGF-1), declines over time until only low levels can be detected in individuals aged ≥60 years. This phenomenon, which is known as the ‘somatopause’, has led to ...

GH/Insulin/insulin-like growth factor 1 (IGF-1) signaling molecules that have been linked to longevity include daf-2 and InR and their homologues in mammals, and inactivation of the corresponding genes increases lifespan in nematodes, fruit flies and mice.

Moreover, mice as well as humans with reduced activity of the GH/IGF-1 axis are protected from cancer and diabetes mellitus, two major ageing-related morbidities. Here, we review data on mouse strains with alterations in the GH/IGF-1 axis and their effects on lifespan.

4 days ago · This study demonstrates that chronic activation of IGF-1 signaling leads to aging-associated senescence at the cellular and organ levels, accompanied by p53-dependent cellular senescence, leading to hair follicle aging. IGF-1, a key growth signaling molecule, is known as essential for the development and maintenance of primary organs, including ...

The insulin-like growth factor-1 (IGF-1) signaling pathway is known as a potent aging modifier, disruption of which consistently associates with lifespan extension across diverse species. Despite this established association, the mechanisms by which IGF-1 signaling modulates organ aging remain poorly understood.

Apr 5, 2012 · Paradoxical effects of insulin-like growth factor (IGF)-1 on atherogenesis and the aging process. IGF-1 blunts multiple processes (in box, left) that are relevant to atherosclerosis development and to vascular aging.

Mar 27, 2025 · Alzheimer’s disease (AD) is a leading cause of dementia, characterized by multifactorial interactions involving genetic, inflammatory, and metabolic dysregulation. Insulin-like growth factor 1 (IGF-I) plays a critical role in maintaining brain homeostasis through neurogenesis, synaptogenesis, and neuroprotection. However, disruptions in IGF-I signaling have been implicated in hallmark AD ...

Mar 27, 2025 · With aging, IGF-1 declines alongside GH output, contributing to muscle loss, decreased bone density, and cognitive decline. Lower IGF-1 levels in older adults increase the risk of frailty and impair regenerative capacity, slowing wound healing and recovery.