Self-amplifying RNA - Wikipedia
Self-amplifying RNA (saRNA), also termed self-replicating RNA (srRNA), is a type of mRNA molecule engineered to replicate itself within host cells, enhancing protein expression and boosting the immune response, making it a promising …
Sarna - Síntomas y causas - Mayo Clinic
La sarna es un trastorno de la piel que provoca sarpullido con picazón y se debe a pequeños ácaros aradores llamados Sarcoptes scabiei. La picazón intensa ocurre en la zona donde el ácaro está cavando. La necesidad de rascarse puede ser más intensa por la noche.
A new generation of vaccines based on alphavirus self-amplifying RNA
In particular, self-amplifying RNA (saRNA) derived from alphavirus expression vectors has shown to be very efficient to induce humoral and cellular responses against many antigens in preclinical models, being superior to non-replicating mRNA and DNA.
Scabies - Diagnosis and treatment - Mayo Clinic
Jul 28, 2022 · To diagnose scabies, your health care provider looks at your skin for symptoms of mites. Your provider may also take a sample of your skin to look at under a microscope. This allows your provider to see if any mites or eggs are present. Scabies treatment involves killing the mites and eggs with a medicated cream or pill.
Self-amplifying RNA vaccines for infectious diseases
Oct 22, 2020 · This review will explore the recent preclinical progress of prophylactic and therapeutic saRNA vaccine candidates, particularly for chronic infectious diseases such as the human...
A self-amplifying RNA RSV prefusion-F vaccine elicits potent
Nov 14, 2024 · We evaluate the immunogenicity of a lipid nanoparticle (LNP)-formulated saRNA vaccine called SMARRT.RSV.preF, encoding a stabilized form of the RSV fusion protein, in female mice and in...
Advances in saRNA Vaccine Research against Emerging/Re …
In this review, we provide an overview of saRNA vaccines, and discuss future directions and challenges in advancing this promising vaccine platform to combat emerging/re-emerging viruses. Keywords: vaccine, self-amplifying RNA (saRNA), emerging/re-emerging virus. 1. Introduction.
Self-copying RNA vaccine wins first full approval: what’s next?
Dec 6, 2023 · But the endorsement last week by Japanese authorities of a jab against SARS-CoV-2 constructed using a form of RNA that can make copies of itself inside cells — the first ‘self-amplifying’ RNA...
Alphaviral backbone of self-amplifying RNA enhances protein
Feb 5, 2025 · Self-amplifying RNA (saRNA) vectors are a next-generation RNA technology that extends the expression of heterologous genes. Clinical trials have shown the dose-sparing capacity of saRNA vectors in a vaccine context compared with conventional messenger RNA.
Small activating RNA - Wikipedia
Small activating RNAs (saRNAs) are double-stranded RNA molecules that induce gene expression at the transcriptional level, a phenomenon known as RNA activation (RNAa).