Human mucins include genes with the HUGO symbol MUC 1 through 22. Of these mucins, the following classes have been defined by localization: [7] [8] [9] [10] Secreted mucins in humans, with their chromosomal location, repeat size in amino acids (aa), whether they are gel-forming (Y) or not (N), and their tissue expression. [11]

Mucin (MUC)-2 is a secreted protein produced by epithelial goblet cells as the main component of mucus. Defects in the gastrointestinal tract, such as inflammation and ulcers, cause damage to the mucus barrier, which can worsen mucus quality and reduce mucus production.

Jun 20, 2022 · Mucin domains are densely O-glycosylated modular protein domains found in various extracellular and transmembrane proteins. Mucin-domain glycoproteins play important roles in many human...

Sep 21, 2021 · Generating the barriers that protect our inner surfaces from bacteria and other challenges requires large glycoproteins called mucins. These come in two flavors, gel-forming and transmembrane, all characterized by large highly O -glycosylated mucin domains diversely decorated by Golgi glycosyltransferases to become extended rod-like structures.

Overexpression of the transmembrane mucins in human cancers has made them highly attractive targets for the development of vaccines, antibodies and drug inhibitors.

Feb 1, 2018 · Mucins are the main structural components of mucus that create a selective protective barrier for epithelial surface and also execute wide range of other physiological functions. Mucins can be classified into two types, namely secreted mucins and membrane bounded mucins.

MUC5B is the predominant mucin in healthy human airways [16, 17, 20], and studies in mice deficient in Muc5b production have shown that Muc5b is essential for MCC and the maintenance of a healthy airway by controlling bacterial infection and resolving inflammation following infection [21].

Mucins are multifunctional glycoproteins that historically were thought to exclusively represent the principal constituent of mucus, protecting and lubricating epithelial surfaces within the human body. New knowledge related to mucin molecular biology indicates that some mucins are additionally involved in signaling pathways that lead to ...

Jul 1, 2021 · Here, we develop a cell-based platform for the display and production of human TR O-glycodomains (~200 amino acids) with tunable structures and patterns of O-glycans using membrane-bound and...

Jul 1, 2021 · Here, we develop a cell-based platform for the display and production of human TR O-glycodomains (~200 amino acids) with tunable structures and patterns of O-glycans using membrane-bound and secreted reporters expressed in glycoengineered HEK293 cells.