Homeobox protein Hox-A1 is a protein that in humans is encoded by the HOXA1 gene. [5][6][7] Two transcript variants encoding two different isoforms have been found for this gene, with only one of the isoforms containing the homeodomain region. [8]

Feb 8, 2025 · Title: Hsa_circ_0074032 promotes prostate cancer progression through elevating homeobox A1 expression by serving as a microRNA-198 decoy. CircRASSF2 acts as a prognostic factor and promotes breast cancer progression by modulating miR-1205/HOXA1 axis.

Dec 25, 2024 · HOXA1 (Homeobox A1) is a Protein Coding gene. Diseases associated with HOXA1 include Athabaskan Brainstem Dysgenesis Syndrome and Bosley-Salih-Alorainy Syndrome . Among its related pathways are RNA Polymerase I Promoter Opening and Nervous system development .

A homeobox is a DNA sequence, around 180 base pairs long, that regulates large-scale anatomical features in the early stages of embryonic development. Mutations in a homeobox may change large-scale anatomical features of the full-grown organism.

Homeobox A1 (HOXA1) is a member of the homeodomain containing transcription factor family which possess a pivotal role during the normal growth and differentiation of mammalian tissues. From: Growth Hormone & IGF Research, 2006

Homeobox A1 (HOXA1) serves an oncogenic role in multiple cancer types. However, the role of HOXA1 in non‑small cell lung cancer (NSCLC) remains unclear. In the present study, use of reverse transcription-quantitative polymerase chain reaction and the databases of The Cancer Genome Atlas (TCGA), Onco …

May 19, 2022 · Objective: Recent studies have demonstrated that homeobox A1 (HOXA1) is upregulated in lung cancer due to RNA modifications (N 6-methyladenosine), but the specific function of HOXA1 in lung adenocarcinoma (LUAD) remains indistinct. Herein, we investigated the role of HOXA1 in LUAD biology.

Jan 15, 2024 · Our findings demonstrated that aberrantly reduced HOXA1 expression induced granulosa cell apoptosis in DOR patients and impaired mitochondrial function, which highlighted the potential role of HOXA1 in the occurrence of DOR …

Jan 15, 2024 · Homeobox gene A1 (HOXA1), a member of the HOX gene family, has been reported to participate in tumorigenesis and decreased expression of HOXA1 could induce cell apoptosis in several types of cancer cells (Belpaire et al., 2022; Liu et al., 2021; Li et al., 2019; Feng et al., 2021; Wei et al., 2021). However, whether the aberrant expression of ...

HOXA1 promotes aerobic glycolysis and cancer progression in cervical cancer. HOXA1 silencing inhibits cisplatin resistance of oral squamous cell carcinoma cells via IkappaB/NF-kappaB signaling pathway. A poly-histidine motif of HOXA1 is involved in regulatory interactions with cysteine-rich proteins.