Mar 30, 2025 · HLA-DPA1 (Major Histocompatibility Complex, Class II, DP Alpha 1) is a Protein Coding gene. Diseases associated with HLA-DPA1 include Hla Modifier and Lymphoma. Among its related pathways are TCR Signaling (Qiagen) and Phosphorylation of …

Major histocompatibility complex, class II, DP alpha 1, also known as HLA-DPA1, is a human gene. [1] The protein encoded by this gene belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane.

Bioinformatics analysis identifies a key gene HLA_DPA1 in severe influenza-associated immune infiltration. HLA-DPA1 overexpression inhibits cancer progression, reduces resistance to cisplatin, and correlates with increased immune infiltration in lung adenocarcinoma.

In this publication, the Type 1 Diabetes Genetic Consortium provides a large scale association analysis of DPA1, DPB1 allele and DPA1-DPB1 haplotypes in a new type 1 diabetes Caucasian family collection combined with existing collections that were re …

We identified HLA-DPA1 as a hub gene in MM related to hypoxia. HLA-DPA1 down-regulated expression was associated with MM patients’ poor outcome. Further functional and mechanistic studies are need to investigate HLA-DPA1 as potential therapeutic target. Keywords: Multiple myeloma, Hypoxia, Prognosis, Bioinformatics analysis. Background

Purpose: Human Leukocyte Antigen-DP alpha 1 (HLA-DPA1) is a critical gene in antigen-presenting cells and plays a significant role in immune regulation. The objective of this study was to comprehensively analyze the roles of HLA-DPA1 and …

Sep 17, 2024 · HLA-DPA1 belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta (DPB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins.

HLA-DPA1 belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an al pha (DPA) and a beta (DPB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins.

[HLA-DPA1] HLA-DPA1 belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta (DPB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins.

Oct 27, 2023 · Decreased HLA-DPA1 expression is associated with poor prognosis and immune infiltration in LUAD while HLA-DPA1 overexpression inhibits cancer cell proliferation and progression. Therefore, HLA-DPA1 shows potential as a prognostic biomarker and a therapeutic target for LUAD.