HLA-B12 (B12) is an HLA - B serotype. B12 is a broad antigen serotype that recognizes the B44 and B45 split antigen serotypes. [1]

HLA region of Chromosome 6. The human leukocyte antigen (HLA) system is a complex of genes on chromosome 6 in humans that encode cell-surface proteins responsible for regulation of the immune system. [1] The HLA system is also known as the human version of the major histocompatibility complex (MHC) found in many animals. [2]

HLA-B12 is a specific subgroup of the HLA-B antigen that has been found to be significantly increased in patients with Stevens-Johnson Syndrome (SJS) with ocular involvement, particularly in Caucasian populations.

HLA-B (major histocompatibility complex, class I, B) is a human gene that provides instructions for making a protein that plays a critical role in the immune system. HLA-B is part of a family of genes called the human leukocyte antigen (HLA) complex.

Apr 24, 2023 · Human leukocyte antigens (HLA) are genes in major histocompatibility complexes (MHC) that help code for proteins that differentiate between self and non-self. They play a significant role in disease and immune defense. They are beneficial to the immune system but can also have detrimental effects.

Jul 18, 2013 · Studies examining HLA class II have consistently replicated the HLA-DR2 (DRB1*15:01), HLA-DR3 (DRB1*03:01), HLA-DRB1*08:01, and HLA-DQA1*01:02 alleles associated with the disease in American and European populations with a two fold RR conferred by each allele (25–28).

Sep 17, 2019 · The HLA-G*01:01:01 phenotype was associated with resistance to HIV-1 infections, and women with HLAG*01:01:01 are significantly less likely to seroconvert than women without this allele. HLA-DRB1*15:02 and HLADRB1*03:01 were associated with low and high viremia, respectively.

In this paper we present the in-depth identification and relative quantification of 14,500 peptide ligands constituting the HLA ligandome of B cells. This large number of identified ligands provides general insight into the presented peptide repertoire and antigen presentation.

The positive association with HLA-B12 among this subgroup was confined to 62 patients with severly impaired vitamin B12 absorption, including 13 patients with vitamin B12 neuromyelopathy, who had the highest frequencies of HLA-B7 and B12.

HLA-B12 was found to be expressed on platelets from each of 25 heterozygous HLA-B12-positive donors in amounts varying about 35-fold from weakest to strongest. Expression of B12 on platelets was enhanced in the presence of the first locus antigen A11, but decreased in the presence of A2, A3, and Aw28.