Mar 31, 2025 · Historically PE rate in high-risk ~ 60%). Perhaps most important is the fact that the vast majority of patients (90%) who had a high pre-test probability had a positive D-Dimer. While a negative age-adjusted D-Dimer may safely exclude PE in a high pretest probability patient, it’s far more likely that the D-Dimer will be positive, resulting ...

Nov 9, 2021 · Pulmonary embolism (PE): A pulmonary embolism is a blood clot in your lung that happens when a clot in another part of your body (often your leg or arm) flows through your bloodstream and becomes lodged in the blood vessels of your lung.

Jan 21, 2025 · D-dimer testing is commonly used to rule out PE in low- and moderate-risk patients due to its high sensitivity and negative predictive value. A negative D-dimer is believed to be inadequate to exclude PE in high-risk patients, and since the test doesn’t change probability, it should be avoided.

Risk stratification immediately guides the management of acute PE, as it determines the need for urgent reperfusion therapy (high-risk PE) and identifies patients who can be safely treated as outpatients (low-risk PE).

Furthermore, the sensitivity of the D-dimer test for PE was very high (approaching 100%). The results suggest that D-dimer could be a simple, fast and inexpensive method for excluding a diagnosis of PE. PE is the third most common acute cardiovascular disease, after myocardial infarction and stroke.

Dec 11, 2024 · Acute pulmonary embolism (PE) occurs when a blood clot that has arisen from another area obstructs the pulmonary arteries. PE typically originates as a deep vein thrombosis (DVT) in the lower extremities. Together, PE and DVT form the spectrum of venous thromboembolism (VTE).

In the 2019 guidelines, there is a definition of haemodynamic instability, which indicates acute high-risk PE.

Apr 1, 2025 · A history of syncope, presyncope, or severe dyspnea increases risk. Physical exam features such as the patient’s general appearance (are they diaphoretic and anxious) and vital signs are important. ... For select patients with intermediate risk PE who are not at high risk of bleeding AND who have severe persistent symptoms with signs of right ...

Mar 11, 2025 · Patients with moderate to high risk for PE according to the Wells score should undergo further testing to confirm potential diagnosis. While there are many tests that can be used to help guide a PE diagnosis (such as D-dimer, V/Q scan, etc), true confirmation should be achieved with a computed tomography pulmonary angiography (CTPA).

Apr 8, 2025 · Pre-test clinical probability scores (pCPS) guide the diagnostic workup of patients with a clinical suspicion of pulmonary embolism (PE) to improve patient outcomes without overburdening healthcare resources [].It has been established that increased imaging doesn’t predict improved patient outcomes [].Additionally, many studies have reported that large proportions (> 50%) of patients with ...