hERG (the human Ether-à-go-go-Related Gene) is a gene that codes for a protein known as K v 11.1, the alpha subunit of a potassium ion channel.

The human ether-a-go-go related gene (hERG) encodes the pore-forming subunit of the rapid component of the delayed rectifier K(+) channel, Kv11.1, which are expressed in the heart, various brain regions, smooth muscle cells, endocrine cells, and a wide range of tumor cell lines.

Jul 1, 2012 · The human ether-a-go-go related gene (hERG) encodes the pore-forming subunit of a delayed rectifier voltage gated K + (VGK) channel. 1 These channels are variously referred to as I Kr, hERG, or Kv11.1 .

Potassium ion channels encoded by the human ether-a-go-go related gene (hERG) form the ion-conducting subunit of the rapid delayed rectifier potassium current (IKr). Although hERG channels exhibit a widespread tissue distribution they play a particularly important role in the heart.

Aug 18, 2011 · Electrical dysfunction of the voltage-sensitive ion channel is associated with potentially lethal ventricular arrhythmias in humans. hERG K + channels are also expressed in a variety of cancer...

Human ether-á-go-go related gene (hERG) potassium (K+) channels play a critical role in cardiac action potential repolarization. This is due, in large part, to the unique gating properties of these channels, which are characterized by relatively ...

Oct 1, 2008 · In this section we discuss the current thinking on the contribution of structural elements in hERG K + channels to their function with specific focus on regulation of channel gating by transmembrane voltage.

The human Ether-a-go-go Related Gene (hERG) potassium channel plays a central role in regulating cardiac excitability and maintenance of normal cardiac rhythm. Mutations in hERG cause a third of all cases of congenital long QT syndrome, a disorder of cardiac repolarisation characterised by prolongat …

In this review, we discuss molecular mechanisms of hERG-associated cell cycle regulation and cell death. In addition, the significance of hERG K + channels as future drug target in anticancer therapy is highlighted. Keywords: hERG, K + channel, cell …

May 1, 2001 · HERG K + channels are important for repolarization of the cardiac action potential and play a specific role in suppressing premature excitation. HERG K + channel blockers are useful in the treatment of atrial arrhythmias.