hERG (the human Ether-à-go-go-Related Gene) is a gene that codes for a protein known as K v 11.1, the alpha subunit of a potassium ion channel. This ion channel (sometimes simply denoted as 'hERG') is best known for its contribution to the electrical activity of the heart : the hERG channel mediates the repolarizing I Kr current in the cardiac ...

The human ether-a-go-go-related gene (hERG) 2 encodes the pore-forming subunit of the rapidly activating delayed rectifier K + channel (I Kr), which plays an important role in the repolarization of cardiac action potentials (2, 3). The ventricular action potential duration is reflected by the QT interval on an electrocardiogram.

Jun 1, 2020 · We provide in this concise review clear guidelines, based on described examples, illustrating successful optimization process to avoid hERG interactions as cases studies and to spur scientists to develop safe drugs.

Jul 1, 2012 · Stimulation of the NH 2-terminal truncated isoform of the androgen receptor has also been shown to stabilize hERG protein half-life . This effect is mediated by phosphorylation of ERK1/2 and is observed both in CHO cells and in isolated rabbit cardiac myocytes.

Our data show that disrupting the interaction between Nedd4-2 and hERG completely abolishes the effects of Rab4 on hERG channels, indicating that Nedd4-2-mediated regulation is the primary pathway for Rab4 to regulate hERG, and the direct effects of Rab4 on hERG trafficking seem to …

Mar 22, 2006 · hERG potassium channels are essential for normal electrical activity in the heart. Inherited mutations in the HERG gene cause long QT syndrome, a disorder that predisposes individuals to...

Sep 28, 2012 · Our data demonstrate that Cav3, hERG, and ubiquitin-ligase Nedd4-2 interact with each other and form a complex. Expression of Cav3 thus enhances the hERG-Nedd4-2 interaction, leading to an increased ubiquitination and degradation of mature, plasma-membrane localized hERG channels.

HERG channels are involved in cardiac action potential repolarization, and reduced function of hERG lengthens ventricular action potentials, prolongs the QT interval in an electrocardiogram, and increases the risk for poten‐ tially fatal ventricular arrhythmias.

Jan 24, 2020 · The KCNH2 gene encodes a voltage sensitive potassium (K +) channel protein, hERG1 (“hERG” for simplicity), which mediates rapid delayed rectifier K + current (I Kr) that makes a major contribution to the repolarization phase of cardiac action potentials, effectively controlling the action potential duration (APD) and QT interval observed in elec...

Nov 19, 1997 · The relatively short and highly basic NH 2 terminals of HERG B and MERG B appear to confer distinct electrophysiological properties compared with those previously reported for HERG A.