ISL1 is a marker for cardiac progenitors of the secondary heart field (SHF) which includes the right ventricle and the outflow tract.

Islet-1 is postulated as a marker of cardiac progenitor cells from the second heart field. Numerous studies suggest Islet1+ cells represent tri-potential precursors of differentiated cardiac tissues including smooth muscle, cardiac muscle and endothelial cells.

One of the key steps in this refinement was the identification of Islet (Isl)1 as a heart field marker (Yuan and Schoenwolf, 2000). Isl1 expression begins as asymmetric fields that encompass the rostrolateral mesoderm at HH4 ( Yuan and Schoenwolf, 2000 ).

Jul 2, 2009 · Scientists have identified a cardiac stem cell that gives rise to all of the major cell types in the human heart. The find opens the way to using patients' own cells to heal their damaged hearts. The cells in question express a protein, called Islet 1, which is present in the early stages of fetal heart formation.

Jun 1, 2011 · Islet-1 expression identifies populations of progenitor cells in embryonic, fetal, and newborn murine hearts that are able to give rise to all cardiac cell lineages ex vivo and in vivo.

Jul 2, 2009 · Recent studies in mice identified multipotent embryonic ISL1+ (Islet 1 expressing) progenitor cells as capable of contributing to all of the major cell types in the heart. Human cardiogenesis...

Oct 1, 2000 · Islet-1 (Isl-1), the LIM domain homeobox gene, is a well-known early marker of neuronal specification. Here, we show its spatial and temporal patterns of expression during early heart and gut development in the chick embryo.

Apr 1, 2007 · Islet1 (Isl1) is a LIM homedomain protein that plays a pivotal role in cardiac progenitors of the second heart field. Here, lineage studies with an inducible isl1-cre demonstrated that most Isl1 progenitors have migrated into the heart by E9.

Oct 17, 2013 · Islet-1 is an important transcription factor for cardiac development through mediating extensive interactions between DNA and proteins. The present study was to investigate the role of Islet-1 in regulating the expression of cardiac development-related transcription factors and mechanism.

Apr 24, 2012 · Adult mammalian cardiac stem cells express the LIM-homeodomain transcription factor Islet1 (Isl1). They are considered remnants of Isl1-positive embryonic cardiac progenitor cells. During amniote heart development, Isl1-positive progenitor cells give rise mainly to the outflow tract, the right ventricle, and parts of the atria.