We found an increased synchronization between the vHPC and mPFC and identified specific mPFC neural subpopulations that selectively respond to object–context associations, and their firing preference correlates with the animals’ behavioral responses.

Nov 17, 2021 · This study revealed that the HPC and mPFC theta oscillations and their temporal coupling is correlated with recognition memory-guided behavior. During novel object recognition, the HPC drives mPFC interneurons to effectively reduce the activity of principal neurons.

Sep 2, 2024 · Here, we showed that neuronal activity in the dHP affects stress-coping behaviors in mice via excitatory projections to the medial prefrontal cortex (mPFC). The antidepressant ketamine rapidly...

Specifically in the HPC-mPFC, alterations in proteins related to AD, such as the decay of calcium-independent phospholipase A2 (iPLA2) and the increase of amyloid-β peptide (Aβ), decreased prefrontal gamma oscillation engagement during spatial working memory (Liu et al., 2016) and abolished CA1-mPFC LTP induction related to spatial working ...

The hippocampal formation (HPC) and medial prefrontal cortex (mPFC) have well-established roles in memory encoding and retrieval. However, the mechanisms underlying interactions between the HPC and mPFC in achieving these functions is not fully ...

Feb 24, 2021 · Here we show that novelty resets the neural circuits that link the ventral hippocampus (vHPC) and the mPFC, facilitating the ability to overcome an established strategy.

A striking finding in the current study is that, in the object-in-place arms, inactivating the mPFC in the HP-CTRL group resulted in almost identical effects on performance (i.e., chance level) seen in the HP-LES group (Fig. 4C).

Here, we showed that neuronal activity in the dHP affects stress-coping behaviors in mice via excitatory projections to the medial prefrontal cortex (mPFC). The antidepressant ketamine rapidly...

Nov 1, 2022 · In this review, we summarize current knowledge on the hippocampal-medial prefrontal cortex (HPC-mPFC) circuit in normal brain function with a focus on oscillations and highlight several neurodevelopmental and neurological disorders associated with …

Sep 15, 2019 · In this study we aimed to characterise changes in neuroinflammation in the medial prefrontal cortex (mPFC) and hippocampus (HP) in a rat model of neuropathic pain (NP) and behavioural changes. 53 rats underwent sciatic nerve chronic constriction injury (CCI) and were characterised as either, No effect, Acute effect or Lasting effect on the ...