HLA-DR2 (DR2) of the HLA-DR serotype system, is a broad antigen serotype that is now preferentially covered by HLA-DR15 and HLA-DR16 serotype group. This serotype primarily recognizes gene products of the HLA-DRB1*15 and HLA-DRB1*16 allele groups.

HLA-DR is an MHC class II cell surface receptor encoded by the human leukocyte antigen complex on chromosome 6 region 6p21.31. The complex of HLA-DR ( H uman L eukocyte A ntigen – DR isotype) and peptide, generally between 9 and 30 amino acids in length, constitutes a ligand for the T-cell receptor (TCR).

HLA-DR2 is a specific genetic marker that is commonly found in nearly 100% of confirmed narcoleptic patients, but its diagnostic value is limited as a significant portion of the general population also tests positive for this marker. AI generated definition based on: Neurology Secrets (Fifth Edition), 2010

Sep 1, 2002 · We report overrepresentation of HLA-DR2 and its serologic split HLA-DR15 in both MDS and aplastic anemia (AA). Four clinically and ethnically defined patient groups were analyzed. The HLA-DR15 antigen frequencies among North American white MDS patients (n = 72) and AA patients (n = 59), who received immunosuppressive treatment at the National ...

Jul 18, 2013 · Studies examining HLA class II have consistently replicated the HLA-DR2 (DRB1*15:01), HLA-DR3 (DRB1*03:01), HLA-DRB1*08:01, and HLA-DQA1*01:02 alleles associated with the disease in American and European populations with a two fold RR conferred by each allele (25–28).

Models of disease susceptibility in multiple sclerosis (MS) often assume a dominant action for the HLA-DRB1*1501 allele and its associated haplotype (DRB1*1501-DQB1*0602 or DR2). A robust and phenotypically well-characterized MS data set was used to ...

With the advent of HLA class II serology, closer associations were found with HLA-DR with an increased frequency of DR3 and DR4 and a decreased frequency of DR2 in T1D subjects. At the population level, the strongest genetic association with T1D is with HLA-DQ alleles.

Apr 4, 2007 · These data provide convincing evidence that particular combinations of HLA Class II DR2 and DR3 haplotypes are key determinants of autoantibody production and disease susceptibility in human...

Sep 9, 1998 · HLA-DR2 is associated with susceptibility to multiple sclerosis (MS). A peptide from human myelin basic protein (MBP, residues 85–99) was previously found to bind to purified HLA-DR2 (DRA, DRB1*1501) and to be recognized by human MBP-specific T cell clones.

Soluble DR2 molecules will allow a detailed characterization of the peptide binding specificity of HLA-DR2 in an effort to define the mechanisms by which this MHC molecule confers susceptibility to multiple sclerosis.