HLA-B57 (B57) is an HLA-B serotype. B57 is a split antigen from the B17 broad antigen, the sister serotype being B58. [2] The serotype identifies the more common HLA-B*57 gene products. …

Sep 1, 2015 · HLA-B*57:01 significantly increases the risk of hypersensitivity reactions when abacavir is administered. Approximately 6% of Caucasians and 2-3% of African Americans …

HIV control is strongly associated with the expression of human leukocyte antigen (HLA) alleles in HICs. From the HIV protective HLAs described, HLA-B57 is the most frequent in HIC patients. …

Abacavir hypersensitivity has been shown to be associated with the human leukocyte antigen (HLA) B*57:01 of the major histocompatibility complex (MHC). The MHC family of genes …

Nov 8, 2018 · Here we explore the impact of micropolymorphism on peptide antigen presentation by three closely related HLA molecules, HLA-B*57:01, HLA-B*57:03 and HLA-B*58:01, that …

The protective effect of HLA-B57 is hypothesised to be due to more efficient presentation of immunogenic HIV peptides to antiviral cytotoxic T lymphocytes than by non-protective HLA …

The HLA-B*57:01 allele has been associated with hypersensitivity to abacavir, a highly effective nucleoside analog reverse-transcriptase inhibitor used to treat HIV infection and AIDS.

First, the HLA-B*57 allele is found in approximately 65% of patients in several different cohorts. 118 In addition, the HIV-specific CD8 + T-cell response in these patients is highly focused on …

HLA-B57 has been associated with slower disease progression in HIV infection, and interestingly, functional differences in HIV immunity are observed in individuals who are HLA-B*5701 + or …

Among people with human immunodeficiency virus (HIV) infection, a version of the HLA-B gene designated HLA-B*5701 increases the risk of an adverse reaction (hypersensitivity) to the drug …