HFD-induced hepatic lipid accumulation and inflammation are …
Oct 16, 2020 · Therefore, the current study investigated the relationship between Factor D and hepatic lipid accumulation using CRISPR/Cas9-mediated Factor D knockout (FD-KO) mice. …
CHIP ameliorates nonalcoholic fatty liver disease via ... - Nature
Oct 2, 2024 · Here, we generate a hepatocyte-specific CHIP knockout (H-KO) mouse model that develops NAFLD more rapidly in response to a high-fat diet (HFD) or high-fat, high-fructose …
Loss of GPR75 protects against non-alcoholic fatty liver disease …
Specifically, HFD-fed female Gpr75 KO mice showed a greater protective effect on lipid accumulation as compared with male Gpr75 KO mice and evidence of browning in white …
Gpr75-deficient mice are protected from high-fat diet-induced
Results: Male and female Gpr75 null (knockout [KO]) and heterozygous mice gained less weight than WT mice when placed on HFD. KO mice maintained the same level of energy …
UCP2 KO mice exhibit ameliorated obesity and inflammation …
HFD-challenged Ucp2 KO mice showed lean phenotypes in terms of body weight, fat composition, actual fat weight, and smaller adipocytes. Additionally, macrophage infiltration, CLS formation, …
Deficiency of ADAR2 ameliorates metabolic-associated fatty liver ...
May 17, 2024 · Herein, we showed that ADAR2 KO effectively prevented HFD-induced NAFLD progression by regulating glucose metabolism dysregulation, insulin resistance, and lipid …
USP13 ameliorates nonalcoholic fatty liver disease through …
Jul 20, 2024 · To prepare in vivo model of NAFLD, mice fed a high-fat diet (HFD) for 16 weeks and leptin-deficient (ob/ob) mice were used. USP13 overexpression and knockout (KO) …
Mice Lacking Gpr75 are Hypophagic and Thin - PMC - National …
Jan 5, 2022 · OGTTs performed on adult Gpr75 KO and WT mice fed HFD from weaning revealed improved glucose tolerance and lower insulin levels in KO mice, confirming published …
High-fat diet induces cardiac remodelling and dysfunction: …
In our study, we report the following novel observations: (i) HFD reduced SIRT3 levels in the heart and caused cardiac systolic dysfunction; (ii) either HFD or SIRT3 KO increased ROS levels, …
Hepatocyte-specific Nrf2 deficiency mitigates high-fat diet …
Feb 1, 2020 · To elucidate the cell-specific role of nuclear factor erythroid-derived 2-like 2 (NRF2) in the pathogenesis of NAFLD, we utilized hepatocyte- and macrophage-specific Nrf2 …
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