Histone deacetylases (EC 3.5.1.98, HDAC) are a class of enzymes that remove acetyl groups (O=C-CH 3) from an ε-N-acetyl lysine amino acid on both histone and non-histone proteins. [2] …

Histone deacetylases (HDACs) are evolutionary conserved enzymes which operate by removing acetyl groups from histones and other protein regulatory factors, with functional consequences …

Histone deacetylase (HDAC) inhibitors are a relatively new class of anti-cancer agents that play important roles in epigenetic or non-epigenetic regulation, inducing death, apoptosis, and cell …

Histone deacetylase inhibitors (HDAC inhibitors, HDACi, HDIs) are chemical compounds that inhibit histone deacetylases. Since deacetylation of histones produces transcriptionally …

Histone deacetylases (HDACs) are part of a vast family of enzymes that have crucial roles in numerous biological processes, largely through their repressive influence on transcription. The …

Histone deacetylases (HDACs) are a group of enzymes that remove acetyl groups from histones, resulting in chromatin condensation and transcriptional repression. They also regulate the …

Aug 18, 2014 · Epigenetic deregulation can underpin the onset and progression of several human diseases. The expression and/or function of histone deacetylases (HDACs) is often perturbed …

Feb 27, 2007 · Histone deacetylases (HDACs) and histone acetyl transferases (HATs) are two counteracting enzyme families whose enzymatic activity controls the acetylation state of …

Sep 1, 2024 · Histone deacetylases (HDACs) are key epigenetic regulators, and transcriptional complexes with deacetylase function are among the epigenetic corepressor complexes in the …

Histone deacetylase (HDAC) is a major class of deacetylation enzymes. HDAC catalyzes the removal of acetyl functional groups from the lysine residues of both histone and nonhistone …