Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 is a protein that in humans is encoded by the HCN4 gene. [5] [6] [7] [8] There are four HCN channels. HCN4 is prominently expressed in the pace maker region of the mammalian heart. [9]

Dec 25, 2024 · Complete information for HCN4 gene (Protein Coding), Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 4, including: function, proteins, disorders, pathways, orthologs, and expression.

HCN4 is the main isoform expressed in the sinoatrial node, but low levels of HCN1 and HCN2 have also been reported. The current through HCN channels, called the pacemaker current ( I f ), plays a key role in the generation and modulation of cardiac rhythmicity , [ 13 ] as they are responsible for the spontaneous depolarization in pacemaker ...

Feb 12, 2018 · HCN4 mutations confer diverse phenotypes, characterized by the previously described bradycardia, sick sinus syndrome, LVNC, mood and anxiety disorders, and susceptibility to VF as described here. Our study clearly suggests that the HCN4-I479V/A485E mutant phenotype can be explained by a lower number of active channels rather than altered ...

Feb 8, 2025 · A novel mutation is found in HCN4 gene causing symptoms of sinus bradycardia in unrelated male Moroccan Jews. These findings suggest HCN4 as a genetic susceptibility factor for mood and anxiety disorders; HCN4 channels are expressed in different patterns in brain and heart; the N terminus is important for HCN4 channel activation

The HCN4 gene provides instructions for making a channel that transports positively charged atoms (ions) into heart muscle cells. This channel is located primarily in the sino-atrial (SA) node, which is an area of specialized cells in the heart that functions as a natural pacemaker.

Nov 3, 2020 · Here the authors use a knockin mouse model expressing cAMP-insensitive HCN4 channels to discover an inhibitory nonfiring cell pool in the sinoatrial node and a tonic and mutual interaction...

Jan 4, 2025 · HCN4 channels are expressed in different patterns in brain and heart; the N terminus is important for HCN4 channel activation; Data show that ablation of HCN4 consistently leads to progressive development of severe bradycardia and AV block, eventually leading to heart arrest and death in about 5 d.

Sep 19, 2024 · HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 Gene ID: 10021, updated on 8-Feb-2025 Gene type: protein coding Also known as: SSS2; EIG18; BRGDA8. See all available tests in GTR for this gene; Go to complete Gene record for HCN4; Go to Variation Viewer for HCN4 variants; Summary

The HCN4 gene encodes a member of the hyperpolarization-activated cyclic nucleotide-gated ion channel family, which are expressed at the cell membrane and contribute to the resting membrane potential.