[Hepatitis B virus (HBV) mutation in enhancer I (HBV Enh I)/X
Objective: To investigate the hepatitis B virus (HBV) mutation in the Enhancer I (HBV Enh I)/X-promoter and to analysis the relationship between chronic HBV-related disease spectrum.
Genetic diversity in enhancer II region of HBV genotype D and its ...
The HBV genome contains two transcriptional enhancer (Enh) regions i.e. Enh-I and Enh-II, which are important for viral replication. The Enh-II, located in nt 1636–1741, overlaps the HBx …
Roles of hepatocyte nuclear factors in hepatitis B virus infection
The HBV genome has four overlapping ORFs and contains several promoters, enhancers, a polyadenylation sequence, and an encapsidation signal. Four promoters are responsible for …
Enhancer I Predominance in Hepatitis B Virus Gene Expression
Our data provides strong evidence for the role of EnhI in regulating global and temporal HBV gene expression. Hepatitis B virus (HBV) is the prototype of the hepadnaviridae, a family of small …
HBV T1719G mutation reduced HBV replication through mutant Enh …
Our results showed that the T1719G mutation impaired viral replication efficacy compared with the wild type both by reducing Enh II activity and binding capacity of HNF3β with Enh II. And such …
Novel X gene point mutations in chronic hepatitis B and HBV …
Jan 1, 2022 · Also, HBx has an important role in the progression of cirrhosis and hepatocellular carcinoma (HCC). This study aimed to determine mutations in X gene, enhancer II (EnhII), and …
Temporal acquisition of sequential mutations in the enhancer II …
Sep 28, 2010 · To investigate the roles of mutations in enhancer II (Enh II) and basal core promoter (BCP) of hepatitis B virus (HBV) in hepatocellular carcinoma (HCC), we determined …
Stronger enhancer II/core promoter activities of hepatitis B virus ...
Jul 27, 2016 · Hepatitis B virus (HBV) genotype C causes prolonged chronic infection and increased risk for liver cancer than genotype B. Our previous work revealed lower replication …
Genetic diversity in enhancer II region of HBV genotype D and its ...
Jan 4, 2022 · The Enh-II region of the HBx gene was sequenced and zanalyzed for polymorphism associated with advanced liver disease. Univariate and logistic regression analyses were …
Role of serum hepatitis B virus marker quantitation to differentiate ...
Patients were classified into four categories: immune tolerant phase (IT, n = 36), immune clearance phase (IC, n = 81), low-replicative phase (LR, n = 31), and HBeAg-negative …
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